SCHEMBL28240232

SCHEMBL28240232

Cc1cccc([Si](C)(C)c2ccccc2)c1C

nearest known ligand 0.42

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ESR1 P03372 1/20 0.42
ESR2 Q92731 1/20 0.42
TRPA1 O75762 2/20 0.37
ATM Q13315 1/20 0.37
TSHR P16473 3/20 0.36
ACHE P22303 1/20 0.36
NR1H2 P55055 1/20 0.35
NR1H3 Q13133 1/20 0.35
LMNA P02545 2/20 0.33
POLB P06746 1/20 0.33
CYP1A2 P05177 2/20 0.33
MEN1 O00255 1/20 0.33
AKR1B10 O60218 1/20 0.33
ABCB11 O95342 1/20 0.33
DHFR P00374 1/20 0.33
MPO P05164 1/20 0.33
CYP3A4 P08684 1/20 0.33
CHRM1 P11229 1/20 0.33
CYP2C9 P11712 1/20 0.33
AKR1B1 P15121 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL988670 0.85 ESR1 (0.46) ESR1ESR2TSHRACHENR1H2
SCHEMBL989100 0.81 TRPA1 (0.38) TRPA1ATMTSHRACHELMNA
SCHEMBL8441760 0.80 ESR1 (0.39) ESR1ESR2NR1H2NR1H3
SCHEMBL1314990 0.80 TRPA1 (0.34) ESR1ESR2TRPA1ATMTSHR
SCHEMBL12191049 0.79 ESR1 (0.54) ESR1ESR2TSHRACHENR1H2
SCHEMBL15107532 0.79 TRPA1 (0.33) TRPA1ATMTSHRACHESMN1; SMN2
SCHEMBL1315179 0.78 TRPA1 (0.35) TRPA1ATMTSHRACHELMNA
SCHEMBL1316141 0.78 TRPA1 (0.35) TRPA1ATMTSHRACHELMNA
SCHEMBL4957410 0.76 TRPA1 (0.34) TRPA1ATMTSHRACHELMNA
SCHEMBL29085715 0.76 TRPA1 (0.31) TRPA1ATMTSHRACHENPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108676604-A A kind of phenyl-fluoride silicon grease and preparation method thereof 天津大学 2018-10-19 CN disclosed