Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.52 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.52 |
| ▸ | HPGD | P15428 | 3/20 | 0.52 |
| ▸ | F2 | P00734 | 1/20 | 0.52 |
| ▸ | ATM | Q13315 | 1/20 | 0.52 |
| ▸ | TTR | P02766 | 3/20 | 0.51 |
| ▸ | CES1 | P23141 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 2/20 | 0.45 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.45 |
| ▸ | NPC1 | O15118 | 1/20 | 0.45 |
| ▸ | MTOR | P42345 | 1/20 | 0.45 |
| ▸ | EPHX2 | P34913 | 2/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 5/20 | 0.43 |
| ▸ | HSP90AA1 | P07900 | 2/20 | 0.43 |
| ▸ | GAA | P10253 | 1/20 | 0.43 |
| ▸ | GFER | P55789 | 1/20 | 0.43 |
| ▸ | NR1H2 | P55055 | 2/20 | 0.43 |
| ▸ | NR1H3 | Q13133 | 2/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2824309 | 1.00 | ALDH1A1 (0.52) | ALDH1A1KMT2AHPGDF2ATM | |
| SCHEMBL13207350 | 1.00 | ALDH1A1 (0.52) | ALDH1A1KMT2AHPGDF2ATM | |
| SCHEMBL13207353 | 0.89 | TTR (0.47) | ALDH1A1KMT2AHPGDF2ATM | |
| SCHEMBL2826794 | 0.89 | TTR (0.47) | ALDH1A1KMT2AHPGDF2ATM | |
| SCHEMBL2826795 | 0.89 | TTR (0.47) | ALDH1A1KMT2AHPGDF2ATM | |
| SCHEMBL2825807 | 0.88 | TTR (0.46) | ALDH1A1KMT2AHPGDF2ATM | |
| SCHEMBL2825805 | 0.88 | TTR (0.46) | ALDH1A1KMT2AHPGDF2ATM | |
| SCHEMBL13207329 | 0.88 | TTR (0.46) | ALDH1A1KMT2AHPGDF2ATM | |
| SCHEMBL13207363 | 0.86 | HSP90AA1 (0.60) | ALDH1A1KMT2AHPGDF2ATM | |
| SCHEMBL2826004 | 0.86 | HSP90AA1 (0.60) | ALDH1A1KMT2AHPGDF2ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781475-B2 | Oxindoles as kinase inhibitors | MERCK PATENT GMBH (DE) | 2010-08-24 | — | — | US | claimed |
| US-20100197757-A1 | OXINDOLES AS KINASE INHIBITORS | BURGDORF LARS THORE | 2010-08-05 | — | — | US | claimed |
| US-20090131506-A1 | Oxindoles as Kinase Inhibitors | MERCK PATENT GMBH (DE) | 2009-05-21 | — | — | US | claimed |
| EP-1891008-A1 | OXINDOLES AS KINASE INHIBITORS | Merck Patent GmbH (DE) | 2008-02-27 | — | — | EP | claimed |
| WO-2006131186-A1 | OXINDOLES AS KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2006-12-14 | — | — | WO | claimed |
| US-7781475-B2 | Oxindoles as kinase inhibitors | MERCK PATENT GMBH (DE) | 2010-08-24 | — | — | US | disclosed |
| US-20100197757-A1 | OXINDOLES AS KINASE INHIBITORS | BURGDORF LARS THORE | 2010-08-05 | — | — | US | disclosed |
| EP-1891008-B1 | OXINDOLES AS KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2010-06-30 | — | — | EP | disclosed |
| US-20090131506-A1 | Oxindoles as Kinase Inhibitors | MERCK PATENT GMBH (DE) | 2009-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197757-A1 | OXINDOLES AS KINASE INHIBITORS | MAP4K2, MAP3K20, MAP3K1 | ALDH1A1 2486/4885KMT2A 1356/4885HPGD 1125/4885 |
| US-20090131506-A1 | Oxindoles as Kinase Inhibitors | MAP4K2, MAP3K20, MAP3K1 | ALDH1A1 2486/4885KMT2A 1356/4885HPGD 1125/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.