Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 11/20 | 0.55 |
| ▸ | MKNK2 | Q9HBH9 | 2/20 | 0.43 |
| ▸ | EGFR | P00533 | 1/20 | 0.36 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.36 |
| ▸ | GSK3A | P49840 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | CDK5 | Q00535 | 1/20 | 0.34 |
| ▸ | TAOK1 | Q7L7X3 | 1/20 | 0.34 |
| ▸ | CLK4 | Q9HAZ1 | 1/20 | 0.34 |
| ▸ | JAK2 | O60674 | 1/20 | 0.34 |
| ▸ | JAK1 | P23458 | 1/20 | 0.34 |
| ▸ | TYK2 | P29597 | 1/20 | 0.34 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.33 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.33 |
| ▸ | ADRA2B | P18089 | 1/20 | 0.33 |
| ▸ | ADRA2C | P18825 | 1/20 | 0.33 |
| ▸ | PRMT5 | O14744 | 1/20 | 0.33 |
| ▸ | WDR77 | Q9BQA1 | 1/20 | 0.33 |
| ▸ | KDR | P35968 | 2/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18797824 | 0.75 | MKNK1 (0.54) | MKNK1MKNK2EGFRERBB2GSK3A | |
| SCHEMBL30564289 | 0.74 | ALDH1A1 (0.42) | ADRA2AADRA2BADRA2C | |
| SCHEMBL18797820 | 0.74 | MKNK1 (0.49) | MKNK1MKNK2EGFRERBB2GSK3A | |
| SCHEMBL18797826 | 0.73 | MKNK1 (0.55) | MKNK1MKNK2EGFRERBB2GSK3A | |
| SCHEMBL27490021 | 0.71 | GRIN2D (0.36) | EGFRADRA2AADRA2BADRA2C | |
| SCHEMBL18815026 | 0.71 | MKNK1 (0.56) | MKNK1MKNK2EGFRERBB2GSK3A | |
| SCHEMBL18786817 | 0.71 | MKNK1 (1.00) | MKNK1MKNK2 | |
| SCHEMBL14843891 | 0.70 | MKNK1 (0.49) | MKNK1MKNK2GSK3ACDK9CDK5 | |
| SCHEMBL18786911 | 0.69 | MKNK1 (0.57) | MKNK1MKNK2EGFRERBB2JAK2 | |
| SCHEMBL18815025 | 0.69 | MKNK1 (0.54) | MKNK1MKNK2EGFRERBB2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108602805-A | Isoindoline, azaisoindoline, indenone and the dihydro azepine indone inhibitor of MNK1 and MNK2 | 效应治疗股份有限公司 | 2018-09-28 | — | — | CN | disclosed |