Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 5/20 | 0.54 |
| ▸ | MEN1 | O00255 | 3/20 | 0.54 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.54 |
| ▸ | HKDC1 | Q2TB90 | 1/20 | 0.54 |
| ▸ | CASP3 | P42574 | 2/20 | 0.53 |
| ▸ | MAPT | P10636 | 2/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.51 |
| ▸ | APAF1 | O14727 | 1/20 | 0.49 |
| ▸ | GAA | P10253 | 1/20 | 0.49 |
| ▸ | SENP8 | Q96LD8 | 1/20 | 0.49 |
| ▸ | SENP7 | Q9BQF6 | 1/20 | 0.49 |
| ▸ | SENP6 | Q9GZR1 | 1/20 | 0.49 |
| ▸ | RAB9A | P51151 | 1/20 | 0.49 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.48 |
| ▸ | P2RX4 | Q99571 | 1/20 | 0.48 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.47 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | CMA1 | P23946 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2644150 | 0.85 | KDM4E (0.66) | KDM4EMEN1KMT2AHKDC1CASP3 | |
| SCHEMBL31370999 | 0.85 | KDM4E (0.53) | KDM4EMEN1KMT2AHKDC1CASP3 | |
| SCHEMBL30296389 | 0.85 | KDM4E (0.66) | KDM4EMEN1KMT2AHKDC1CASP3 | |
| SCHEMBL2643348 | 0.83 | KDM4E (0.54) | KDM4EMEN1KMT2AHKDC1CASP3 | |
| SCHEMBL2644601 | 0.83 | KDM4E (0.51) | KDM4EMEN1KMT2AHKDC1CASP3 | |
| SCHEMBL2644659 | 0.82 | FFAR1 (0.55) | KDM4EMEN1KMT2AHKDC1CASP3 | |
| SCHEMBL2643782 | 0.81 | KDM4E (0.52) | KDM4EMEN1KMT2AHKDC1CASP3 | |
| SCHEMBL17366179 | 0.81 | MDM2 (0.55) | KDM4EMEN1KMT2AHKDC1CASP3 | |
| SCHEMBL30296312 | 0.80 | MEN1 (0.51) | KDM4EMEN1KMT2AHKDC1CASP3 | |
| SCHEMBL2643804 | 0.80 | MEN1 (0.51) | KDM4EMEN1KMT2AHKDC1CASP3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108602805-A | Isoindoline, azaisoindoline, indenone and the dihydro azepine indone inhibitor of MNK1 and MNK2 | 效应治疗股份有限公司 | 2018-09-28 | — | — | CN | disclosed |