Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 7/20 | 0.73 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.73 |
| ▸ | L3MBTL1 | Q9Y468 | 3/20 | 0.64 |
| ▸ | RAB9A | P51151 | 2/20 | 0.64 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.63 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.55 |
| ▸ | PPARG | P37231 | 1/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | EGFR | P00533 | 1/20 | 0.48 |
| ▸ | DGAT1 | O75907 | 1/20 | 0.48 |
| ▸ | TRPV1 | Q8NER1 | 1/20 | 0.48 |
| ▸ | BRD4 | O60885 | 1/20 | 0.48 |
| ▸ | POLB | P06746 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4377962 | 0.85 | MAPT (0.68) | MAPTALDH1A1L3MBTL1RAB9ASMN1; SMN2 | |
| SCHEMBL1399272 | 0.85 | MAPT (0.68) | MAPTALDH1A1RAB9ASMN1; SMN2PPARG | |
| SCHEMBL1431034 | 0.83 | RAB9A (0.67) | MAPTALDH1A1L3MBTL1RAB9ASMN1; SMN2 | |
| SCHEMBL17254232 | 0.83 | RAB9A (0.56) | MAPTALDH1A1L3MBTL1RAB9ASMN1; SMN2 | |
| SCHEMBL5740173 | 0.79 | MAPT (0.77) | MAPTL3MBTL1RAB9ASMN1; SMN2KMT2A | |
| SCHEMBL13761492 | 0.79 | RAB9A (0.53) | MAPTALDH1A1L3MBTL1RAB9ASMN1; SMN2 | |
| SCHEMBL8162830 | 0.78 | SMO (0.50) | MAPTALDH1A1L3MBTL1RAB9ASMN1; SMN2 | |
| SCHEMBL23245914 | 0.78 | RAB9A (0.60) | MAPTALDH1A1L3MBTL1RAB9ASMN1; SMN2 | |
| SCHEMBL14926640 | 0.77 | RAB9A (0.80) | MAPTL3MBTL1RAB9ASMN1; SMN2KDM4E | |
| Hydrochloric Acid SCHEMBL23245938 | 0.77 | RAB9A (0.58) | MAPTALDH1A1L3MBTL1RAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 28 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1824829-B1 | 3-SUBSTITUTED PYRIDINE DERIVATIVES AS H3 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-05-05 | — | — | EP | claimed |
| CN-101068786-A | 3-substituted pyridine derivatives as h3 antagonists | HOFFMANN LA ROCHE (CH) | 2007-11-07 | — | — | CN | claimed |
| EP-1824829-A1 | 3-SUBSTITUTED PYRIDINE DERIVATIVES AS H3 ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2007-08-29 | — | — | EP | claimed |
| US-20060122187-A1 | Pyridine derivatives as H3 antagonists | F. HOFFMANN-LA ROCHE AG (CH) | 2006-06-08 | — | — | US | claimed |
| WO-2006058649-A1 | 3-SUBSTITUTED PYRIDINE DERIVATIVES AS H3 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-06-08 | — | — | WO | claimed |
| US-20170008848-A1 | METHODS OF MAKING NETUPITANT AND INTERMEDIATES THEREOF | MYLAN API US LLC | 2017-01-12 | — | — | US | disclosed |
| US-20170008848-A1 | METHODS OF MAKING NETUPITANT AND INTERMEDIATES THEREOF | MYLAN API US LLC | 2017-01-12 | — | — | US | disclosed |
| US-20160368875-A1 | METHODS OF MAKING NETUPITANT AND INTERMEDIATES THEREOF | MYLAN API US LLC | 2016-12-22 | — | — | US | disclosed |
| US-20160368875-A1 | METHODS OF MAKING NETUPITANT AND INTERMEDIATES THEREOF | MYLAN API US LLC | 2016-12-22 | — | — | US | disclosed |
| US-20150315149-A1 | METHODS OF MAKING NETUPITANT AND INTERMEDIATES THEREOF | MYLAN API US LLC | 2015-11-05 | — | — | US | disclosed |
| US-20150315149-A1 | METHODS OF MAKING NETUPITANT AND INTERMEDIATES THEREOF | MYLAN API US LLC | 2015-11-05 | — | — | US | disclosed |
| EP-1824829-B1 | 3-SUBSTITUTED PYRIDINE DERIVATIVES AS H3 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-05-05 | — | — | EP | disclosed |
| EP-1035115-B1 | 4-Phenylpyridine derivatives and their use as NK-1 receptor antagonists | HOFFMANN LA ROCHE (CH) | 2004-09-29 | — | — | EP | disclosed |
| CN-1142144-C | 4-phenyl pyridine derivatives | - | 2004-03-17 | — | — | CN | disclosed |
| EP-1394150-A1 | 4-Phenylpyridine derivatives and their use as NK-1 receptor antagonists | F. HOFFMANN-LA ROCHE AG (CH) | 2004-03-03 | — | — | EP | disclosed |
| US-6479483-B2 | 3,4,6-SUBSTITUTED PYRIDINE DERIVATIVES USEFUL FOR TREATING DEPRESSION AND PAIN, RESULTING FROM INFLAMMATORY CONDITIONS, SUCH AS MIGRAINE, RHEUMATOID ARTHRITIS, ASTHMA AND INFLAMATORY BOWEL DISEASE; NK1 RECEPTOR ANTAGONIST | HOFFMANN-LA ROCHE INC. | 2002-11-12 | — | — | US | disclosed |
| US-20020091265-A1 | 4-phenyl-pyridine derivatives | BOS MICHAEL (CA) | 2002-07-11 | — | — | US | disclosed |
| US-6297375-B1 | 4-phenyl-pyridine derivatives | HOFFMANN-LA ROCHE INC. | 2001-10-02 | — | — | US | disclosed |
| CN-1270959-A | 4-phenyl pyridine derivatives | HOFFMANN LA ROCHE (CH) | 2000-10-25 | — | — | CN | disclosed |
| EP-1035115-A1 | 4-Phenylpyridine derivatives and their use as NK-1 receptor antagonists | F. HOFFMANN-LA ROCHE AG (CH) | 2000-09-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (5 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20060122187-A1 | Pyridine derivatives as H3 antagonists | HRH3, HRH4, HRH2 | MAPT 2111/4885ALDH1A1 586/4885L3MBTL1 2623/4885 |
| US-20160368875-A1 | METHODS OF MAKING NETUPITANT AND INTERMEDIATES THEREOF | NMUR1, NNT, NMUR2 | MAPT 2122/4885ALDH1A1 1015/4885L3MBTL1 4676/4885 |
| US-20170008848-A1 | METHODS OF MAKING NETUPITANT AND INTERMEDIATES THEREOF | NMUR1, NNT, NMUR2 | MAPT 2122/4885ALDH1A1 1015/4885L3MBTL1 4676/4885 |
| US-20020091265-A1 | 4-phenyl-pyridine derivatives | CBR1, CBR3, HCCS | MAPT 4733/4885ALDH1A1 1775/4885L3MBTL1 1978/4885 |
| US-20150315149-A1 | METHODS OF MAKING NETUPITANT AND INTERMEDIATES THEREOF | NMUR1, NNT, NMUR2 | MAPT 2122/4885ALDH1A1 1015/4885L3MBTL1 4676/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.