Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.60 |
| ▸ | PLA2G10 | O15496 | 2/20 | 0.51 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.50 |
| ▸ | IDO1 | P14902 | 1/20 | 0.49 |
| ▸ | TDO2 | P48775 | 1/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | ADORA2A | P29274 | 1/20 | 0.48 |
| ▸ | ADORA1 | P30542 | 1/20 | 0.48 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.47 |
| ▸ | PKM | P14618 | 3/20 | 0.47 |
| ▸ | MRGPRX4 | Q96LA9 | 2/20 | 0.47 |
| ▸ | NPC1 | O15118 | 1/20 | 0.47 |
| ▸ | MITF | O75030 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | FOLH1 | Q04609 | 2/20 | 0.46 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL9027681 | 0.84 | TDP1 (0.72) | TDP1KMT2APOLBHTTPKM | |
| SCHEMBL29703247 | 0.84 | TDP1 (0.72) | TDP1KMT2APOLBHTTPKM | |
| SCHEMBL25202643 | 0.84 | IDO1 (0.44) | TDP1KMT2AIDO1TDO2POLB | |
| SCHEMBL31051620 | 0.84 | IDO1 (0.44) | TDP1KMT2AIDO1TDO2POLB | |
| Hydrochloric Acid SCHEMBL30088832 | 0.82 | TDP1 (0.70) | TDP1KMT2APOLBHTTPKM | |
| SCHEMBL28245455 | 0.80 | TDP1 (0.60) | TDP1PLA2G10KMT2APOLBPKM | |
| SCHEMBL19011632 | 0.79 | HTT (0.67) | TDP1KMT2AIDO1TDO2POLB | |
| SCHEMBL28244750 | 0.78 | TDP1 (0.51) | TDP1PLA2G10KMT2APOLBPKM | |
| SCHEMBL31051571 | 0.75 | TDP1 (0.42) | TDP1PLA2G10IDO1TDO2ADORA2A | |
| SCHEMBL25180564 | 0.75 | TDP1 (0.42) | TDP1PLA2G10IDO1TDO2ADORA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108558773-A | A kind of preparation method of olaparib pharmaceutical intermediate | 苏州莱克施德药业有限公司 | 2018-09-21 | — | — | CN | claimed |