Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.60 |
| ▸ | RXFP1 | Q9HBX9 | 3/20 | 0.46 |
| ▸ | PKM | P14618 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.46 |
| ▸ | NPC1 | O15118 | 2/20 | 0.44 |
| ▸ | RAB9A | P51151 | 2/20 | 0.44 |
| ▸ | MITF | O75030 | 1/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.43 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.43 |
| ▸ | LMNA | P02545 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.43 |
| ▸ | PLA2G10 | O15496 | 1/20 | 0.43 |
| ▸ | POLB | P06746 | 3/20 | 0.42 |
| ▸ | GAA | P10253 | 2/20 | 0.41 |
| ▸ | APOBEC3G | Q9HC16 | 1/20 | 0.41 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL31140178 | 0.82 | PARP1 (0.57) | TDP1 | |
| SCHEMBL30495895 | 0.82 | TDP1 (0.50) | TDP1 | |
| SCHEMBL31656091 | 0.81 | PARP1 (0.59) | TDP1 | |
| Hydrochloric Acid SCHEMBL2253051 | 0.81 | PTGER4 (0.41) | TDP1ALDH1A1KDM4ELMNAGAA | |
| SCHEMBL28244751 | 0.80 | TDP1 (0.60) | TDP1PKMALDH1A1NPC1RAB9A | |
| SCHEMBL29703239 | 0.79 | TDP1 (0.69) | TDP1RXFP1PKMALDH1A1NPC1 | |
| SCHEMBL7894526 | 0.79 | TDP1 (0.69) | TDP1RXFP1PKMALDH1A1NPC1 | |
| SCHEMBL29463417 | 0.78 | PARP1 (0.56) | TDP1 | |
| SCHEMBL30141798 | 0.78 | PARP1 (0.48) | TDP1 | |
| SCHEMBL29703247 | 0.78 | TDP1 (0.72) | TDP1RXFP1PKMALDH1A1NPC1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108558773-A | A kind of preparation method of olaparib pharmaceutical intermediate | 苏州莱克施德药业有限公司 | 2018-09-21 | — | — | CN | disclosed |