Piperazine

Piperazine

SCHEMBL282455

C1CNCCN1.Cl.Cl

nearest known ligand 0.00

Full drug profile on Sugi Atlas →

Known targets — ChEMBL curated mechanism

ESR1

The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.

⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
Piperazine SCHEMBL3062535 1.00 HIF1A (0.86)
Piperazine SCHEMBL7690 1.00
Hydrochloric Acid SCHEMBL16226020 1.00 HIF1A (0.86)
Hydrochloric Acid SCHEMBL4769861 1.00 HIF1A (0.86)
Hydrochloric Acid SCHEMBL11801121 1.00 HIF1A (0.86)
Piperazine SCHEMBL20258219 1.00 HIF1A (0.86)
Hydrochloric Acid SCHEMBL11707528 1.00 HIF1A (0.86)
Piperazine SCHEMBL6598522 1.00 HIF1A (0.86)
Piperazine SCHEMBL4467850 1.00
Hydrochloric Acid SCHEMBL5568840 1.00 HIF1A (0.86)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 548 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
US-20250386747-A1 TIN BASED PEROVSKITE FIELD EFFECT TRANSISTOR MEMORY AND METHOD OF MANUFACTURING SAME POSTECH RES & BUSINESS DEV FOUND (KR) 2025-12-18 US claimed
EP-4663645-A1 TIN BASED PEROVSKITE FIELD EFFECT TRANSISTOR MEMORY AND METHOD OF MANUFACTURING SAME POSTECH Research and Business Development Foundation (KR) 2025-12-17 EP claimed
CN-119255620-A Perovskite solar cell structure, preparation method and cell 江苏先导微电子科技有限公司 2025-01-03 CN claimed
CN-116143724-A Preparation method and application of piperazine chloride 中国科学院宁波材料技术与工程研究所 2023-05-23 CN claimed
CN-114671830-A Preparation method of biguanide derivative hydrochloride 西安石油大学 2022-06-28 CN claimed
CN-109400549-A The new preparation method of one kind of 1- [ 2-(2- hydroxyl-oxethyl) ethyl ] piperazine hydrochloride 无锡乾浩生物医药有限公司 2019-03-01 CN claimed
CN-109384744-A The new preparation method of one kind of 1- (2- chloroethyl) -4- methyl piperazine 南京海燕生物医药科技有限公司 2019-02-26 CN claimed
CN-109384743-A The new preparation method of one kind of 1- [2- (2- hydroxyl-oxethyl) ethyl] piperazine hydrochloride 南京海燕生物医药科技有限公司 2019-02-26 CN claimed
CN-109010342-A Pharmaceutical composition and method for acute-on-chronic liver failure and related liver disease 方明 2018-12-18 CN claimed
CN-106366051-A Synthesis method of cinnamyl piperazine 郑州瑞康制药有限公司 2017-02-01 CN claimed
EP-1233991-A2 PROCESS FOR THE PREPARATION OF A COATING, A COATED SUBSTRATE, AN ADHESIVE, A FILM OR SHEET, FOR THE THUS OBTAINED PRODUCTS AND THE COATING MIXTURE TO BE USED IN THE PROCESS STAHL INTERNATIONAL B.V. (NL) 2002-08-28 EP claimed
CN-1083448-C 1-phenyl-4-benzylpiperazines: dopamine receptor subtype specific ligands (D4) NEUROGEN CORP (US) 2002-04-24 CN claimed
WO-2001023451-A2 PROCESS FOR THE PREPARATION OF A COATING, A COATED SUBSTRATE, AN ADHESIVE, A FILM OR SHEET, FOR THE THUS OBTAINED PRODUCTS AND THE COATING MIXTURE TO BE USED IN THE PROCESS STAHL INTERNATIONAL B.V. (NL) 2001-04-05 WO claimed
CN-1250444-A 1-phenyl-4-benzylpiperazines: dopamine receptor subtype specific ligands (D4) NEUROGEN CORP (US) 2000-04-12 CN claimed
EP-0945496-A1 Ink compositions and multicolor thermal ink jet printing process for the production of high quality images Xerox Corporation (US) 1999-09-29 EP claimed
US-5958121-A SET OF INKS COMPRISING FIRST AQUEOUS INK CONSISTING OF ANIONIC COLORANT, SECOND AQUEOUS INK CONTAINING AMMONIUM SALT, WHEREIN FIRST COLORANT IS IMMOBILIZED ON SUBSTRATE BY INTERACTION WITH AMMONIUM SALT, REDUCING INTERCOLOR BLEED XEROX CORPORATION (US) 1999-09-28 US claimed
EP-0898567-A1 NOVEL N-AMINOALKYL-1-BIPHENYLENYL-2-CARBOXAMIDES; NEW DOPAMINE RECEPTOR SUBTYPE SPECIFIC LIGANDS NEUROGEN CORPORATION (US) 1999-03-03 EP claimed
WO-1997038990-A1 NOVEL N-AMINOALKYL-1-BIPHENYLENYL-2-CARBOXAMIDES; NEW DOPAMINE RECEPTOR SUBTYPE SPECIFIC LIGANDS NEUROGEN CORPORATION (US) 1997-10-23 WO claimed
US-4556509-A IMPROVES WATER FOAMING AND DEGREASING COLGATE-PALMOLIVE COMPANY (US) 1985-12-03 US claimed
US-4003988-A POLYMERIC LATEX PARTICLES COATED WITH HUMAN CHORIONIC GONADOTROPIN ANTI-SERUM; BUFFERS WARNER-LAMBERT COMPANY (US) 1977-01-18 US claimed