Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Piperazine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Piperazine SCHEMBL3062535 | 1.00 | HIF1A (0.86) | — | |
| Hydrochloric Acid SCHEMBL16226020 | 1.00 | HIF1A (0.86) | — | |
| Hydrochloric Acid SCHEMBL4769861 | 1.00 | HIF1A (0.86) | — | |
| Hydrochloric Acid SCHEMBL11801121 | 1.00 | HIF1A (0.86) | — | |
| Piperazine SCHEMBL282455 | 1.00 | — | — | |
| Piperazine SCHEMBL20258219 | 1.00 | HIF1A (0.86) | — | |
| Hydrochloric Acid SCHEMBL11707528 | 1.00 | HIF1A (0.86) | — | |
| Piperazine SCHEMBL6598522 | 1.00 | HIF1A (0.86) | — | |
| Piperazine SCHEMBL4467850 | 1.00 | — | — | |
| Hydrochloric Acid SCHEMBL5568840 | 1.00 | HIF1A (0.86) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1304 patents — showing the first 20. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-118028873-A | D is used as2Method for preparing deuterated piperazine by using O as deuterium source through electrocatalytic effect | 天津大学 | 2024-05-14 | — | — | CN | claimed |
| WO-2023166975-A1 | PEPTIDE COMPOUND PRODUCTION METHOD | 国立大学法人徳島大学 | 2023-09-07 | — | — | WO | claimed |
| CN-113176253-B | Occult blood indicator for animal excrement and application thereof | 上海麦可信生物科技有限公司 | 2023-05-23 | — | — | CN | claimed |
| CN-116143724-A | Preparation method and application of piperazine chloride | 中国科学院宁波材料技术与工程研究所 | 2023-05-23 | — | — | CN | claimed |
| CN-115557902-A | Preparation method of N- (2-pyrimidine) piperazine hydrochloride | 武汉海特生物创新医药研究有限公司 | 2023-01-03 | — | — | CN | claimed |
| CN-113501796-B | Aminoethylated piperazine and preparation method thereof | 大连理工大学 | 2022-08-26 | — | — | CN | claimed |
| CN-110606830-B | Method for producing piperaquine phosphate intermediate quinoline piperazine hydrochloride by applying piperazine | 珠海润都制药股份有限公司 | 2022-03-18 | — | — | CN | claimed |
| CN-109962289-B | Electrolyte composition and metal ion battery comprising same | 财团法人工业技术研究院 | 2022-03-11 | — | — | CN | claimed |
| CN-113501796-A | Aminoethylated piperazine and preparation method thereof | 大连理工大学 | 2021-10-15 | — | — | CN | claimed |
| CN-113176253-A | Animal excrement occult blood indicator and application thereof | 上海麦可信生物科技有限公司 | 2021-07-27 | — | — | CN | claimed |
| CN-1944404-A | Indolyl alkyl-amine compounds and their preparing method and use in medicine production | CHINA UNIV OF PHARMACY (CN) | 2007-04-11 | — | — | CN | claimed |
| WO-2006064015-A2 | DIPHENYLUREA DERIVATIVES USEFUL AS POTASSIUM CHANNEL ACTIVATORS | NEUROSEARCH A/S (DK) | 2006-06-22 | — | — | WO | claimed |
| CN-1227241-C | Having 5-hydroxytryptamine 1AReceptor-active arylpiperazines | LILLY CO ELI (US) | 2005-11-16 | — | — | CN | claimed |
| US-6955814-B1 | protecting and/or preserving organs, in particular the heart during open-heart surgery, cardiovascular diagnosis or therapeutic intervention by administering potassium channel opener or agonist and adenosine receptor agonist and local anesthetic | GLOBAL CARDIAC SOLUTIONS PTY LTD. (AU) | 2005-10-18 | — | — | US | claimed |
| CN-1469863-A | Crystalline forms of 1- [ 6-chloro-5- (trifluoromethyl) -2-pyridinyl ] piperazine hydrochloride | ��˹��ŵ�� | 2004-01-21 | — | — | CN | claimed |
| CN-1399654-A | Process for the preparation of coating, coated substrate, adhesive, film or sheet, for the thus obtained products and the coating mixture to be used in the process | STAHL INT BV (NL) | 2003-02-26 | — | — | CN | claimed |
| CN-1344135-A | Organ arrest, protection and preservation | UNIV JAMES COOK (AU) | 2002-04-10 | — | — | CN | claimed |
| CN-1308629-A | Reduced partide size form of 1-(6-chloronaphth-2-ylsulphonyl)-4-[4-(4-pyridyl)benzoyl] piperazine | ZENECA ZENECA AB (SE) | 2001-08-15 | — | — | CN | claimed |
| CN-1290258-A | Aryl piperazine compounds with 5-hydroxytryptamine 1A receptor activity | LILLY CO ELI (US) | 2001-04-04 | — | — | CN | claimed |
| WO-1997022638-A1 | COMPOSITIONS AND PROCESSES FOR TREATING SUBTERRANEAN FORMATIONS | PHILLIPS PETROLEUM COMPANY (US) | 1997-06-26 | — | — | WO | claimed |