Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Bicarbonate. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | LMNA | P02545 | 1/20 | 0.58 |
| ▸ | PKM | P14618 | 1/20 | 0.58 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.56 |
| ▸ | HPGD | P15428 | 2/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.55 |
| ▸ | TRPA1 | O75762 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.55 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.51 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.51 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.51 |
| ▸ | LTB4R | Q15722 | 3/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.50 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.50 |
| ▸ | S1PR2 | O95136 | 1/20 | 0.50 |
| ▸ | S1PR4 | O95977 | 1/20 | 0.50 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.50 |
| ▸ | S1PR3 | Q99500 | 1/20 | 0.50 |
| ▸ | ALOX5 | P09917 | 1/20 | 0.50 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.50 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7263621 | 0.92 | SIGMAR1 (0.53) | LMNAPKM | |
| SCHEMBL11749172 | 0.92 | SIGMAR1 (0.53) | LMNAPKM | |
| SCHEMBL11099209 | 0.92 | SIGMAR1 (0.53) | LMNAPKM | |
| SCHEMBL1299996 | 0.92 | SIGMAR1 (0.53) | LMNAPKM | |
| SCHEMBL6568208 | 0.92 | SIGMAR1 (0.53) | LMNAPKM | |
| SCHEMBL7864102 | 0.92 | SIGMAR1 (0.53) | LMNAPKM | |
| SCHEMBL6569356 | 0.92 | SIGMAR1 (0.53) | LMNAPKM | |
| SCHEMBL8332808 | 0.92 | SIGMAR1 (0.53) | LMNAPKM | |
| SCHEMBL21802444 | 0.92 | SIGMAR1 (0.53) | LMNAPKM | |
| Ammonia Solution, Strong SCHEMBL3127075 | 0.90 | SIGMAR1 (0.52) | LMNAPKM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-104640837-B | Method using vapor recompression for continuously preparing aryl carbonate Arrcostab and/or diaryl carbonate | 沙特基础全球技术有限公司 | 2018-09-25 | — | — | CN | disclosed |