SCHEMBL28246736

SCHEMBL28246736

CC(C)(Cc1ccc(C#N)cc1)C(=O)O.[Zn]

nearest known ligand 0.56

Predicted protein targets (top 16)

geneUniProtsupporting neighboursconfidence
SLC22A12 Q96S37 4/20 0.56
HTT P42858 1/20 0.46
CYP2A6 P11509 1/20 0.46
EPHX2 P34913 1/20 0.46
CTBP2 P56545 1/20 0.45
PPARA Q07869 3/20 0.43
PPARD Q03181 2/20 0.43
LOXL2 Q9Y4K0 2/20 0.43
SAE1 Q9UBE0 1/20 0.42
UBA2 Q9UBT2 1/20 0.42
BLM P54132 1/20 0.41
RAB9A P51151 1/20 0.40
MMP12 P39900 1/20 0.40
MMP13 P45452 1/20 0.40
GSK3B P49841 1/20 0.40
NSD2 O96028 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27945030 0.98 SLC22A12 (0.57) SLC22A12HTTCYP2A6EPHX2CTBP2
SCHEMBL6371871 0.84 CYP2A6 (0.47) SLC22A12HTTCYP2A6EPHX2CTBP2
SCHEMBL7290869 0.84 HTT (0.47) SLC22A12HTTCYP2A6EPHX2CTBP2
SCHEMBL8694396 0.81 BLM (0.65) SLC22A12HTTCYP2A6EPHX2CTBP2
SCHEMBL9250987 0.80 HTT (0.50) SLC22A12HTTCYP2A6EPHX2CTBP2
SCHEMBL28246706 0.77 HIF1A (0.55) PPARABLM
SCHEMBL27925093 0.77 ESR1 (0.56) SLC22A12PPARABLM
SCHEMBL10029148 0.76 CYP2A6 (0.46) SLC22A12HTTCYP2A6EPHX2CTBP2
SCHEMBL11596247 0.76 BLM (0.67) BLM
SCHEMBL4457891 0.76 BLM (0.47) CTBP2PPARABLMRAB9A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108586500-A Zinc co-ordination complex and the method for preparing organic zinc reagent 慕尼黑路德维希马克西米利安斯大学 2018-09-28 CN disclosed