SCHEMBL4457891

SCHEMBL4457891

Cc1ccc(CC(C)(C)C(=O)O)cc1

nearest known ligand 0.48

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
BLM P54132 1/20 0.47
L3MBTL1 Q9Y468 2/20 0.46
KDM4E B2RXH2 1/20 0.46
CYP2C9 P11712 2/20 0.45
HPGD P15428 1/20 0.44
SMN1; SMN2 Q16637 4/20 0.43
PPARA Q07869 3/20 0.43
CTBP2 P56545 1/20 0.43
SRD5A2 P31213 1/20 0.43
NPC1 O15118 1/20 0.42
RAB9A P51151 1/20 0.42
TDP1 Q9NUW8 2/20 0.41
TTR P02766 1/20 0.41
CYP1A2 P05177 1/20 0.41
CYP2C8 P10632 1/20 0.41
CHRM1 P11229 1/20 0.41
TSHR P16473 1/20 0.41
ADRA1A P35348 1/20 0.41
PPARG P37231 1/20 0.41
HTR2B P41595 1/20 0.41

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL6778826 0.87 FFAR1 (0.61) BLML3MBTL1KDM4EHPGDSMN1; SMN2
SCHEMBL27925093 0.85 ESR1 (0.56) BLML3MBTL1KDM4EHPGDSMN1; SMN2
SCHEMBL11596247 0.83 BLM (0.67) BLMKDM4EHPGDTDP1CYP1A2
SCHEMBL6668736 0.83 BLM (0.52) BLML3MBTL1KDM4EHPGDSMN1; SMN2
SCHEMBL8951998 0.83 HPGD (0.44) BLML3MBTL1HPGDSMN1; SMN2CTBP2
SCHEMBL12659250 0.83 HPGD (0.44) BLMHPGDSMN1; SMN2CTBP2SRD5A2
SCHEMBL517462 0.83 SMN1; SMN2 (0.57) BLMCYP2C9SMN1; SMN2PPARACYP1A2
SCHEMBL23582821 0.82 CA2 (0.52) BLMKDM4EHPGDSMN1; SMN2PPARA
SCHEMBL10973409 0.82 BLM (0.46) BLML3MBTL1KDM4ECYP2C9HPGD
SCHEMBL6469200 0.82 GRN (0.54) BLML3MBTL1KDM4ECYP2C9HPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 17 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-2065360-B1 Use of 3-methylbenzyl isobutyrate as a fragrance compound SYMRISE AG (DE) 2013-06-19 EP disclosed
EP-2206749-B1 PHTHALOCYANINE COMPOUND NISSAN CHEMICAL IND LTD (JP) 2012-11-21 EP disclosed
US-8304536-B2 Phthalocyanine compound NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2012-11-06 US disclosed
US-8304536-B2 Phthalocyanine compound NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2012-11-06 US disclosed
CN-101448791-B Fxr agonists LILLY CO ELI 2011-11-16 CN disclosed
US-20100228021-A1 PHTHALOCYANINE COMPOUND NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2010-09-09 US disclosed
US-20100228021-A1 PHTHALOCYANINE COMPOUND NISSAN CHEMICAL INDUSTRIES, LTD. (JP) 2010-09-09 US disclosed
EP-2206749-A1 PHTHALOCYANINE COMPOUND Nissan Chemical Industries, Ltd. (JP) 2010-07-14 EP disclosed
EP-2065360-A2 3-methylbenzyl isobutyrate Symrise GmbH & Co. KG (DE) 2009-06-03 EP disclosed
EP-1747186-B1 Fragrant composition comprising 3-methylbenzyl-isobutyrat SYMRISE GMBH & CO KG (DE) 2009-03-11 EP disclosed
US-7253158-B2 Sulfonamides HOFFMANN-LA ROCHE INC. (US) 2007-08-07 US disclosed
EP-1747186-A1 3-METHYLBENZYL-ISOBUTYRAT Symrise GmbH & Co. KG (DE) 2007-01-31 EP disclosed
WO-2006005486-A1 SULFONAMIDE DERIVATIVES F. HOFFMANN-LA ROCHE AG (CH) 2006-01-19 WO disclosed
WO-2005110967-A1 3-METHYLBENZYL-ISOBUTYRAT SYMRISE GMBH & CO. KG (DE) 2005-11-24 WO disclosed
EP-0292889-B1 BENZALDEHYDE DERIVATIVES, THEIR PREPARATION AND USE BASF Aktiengesellschaft (DE) 1992-09-02 EP disclosed
EP-0292889-A2 Benzaldehyde derivatives, their preparation and use BASF Aktiengesellschaft (DE) 1988-11-30 EP disclosed
US-4166131-A ANTIINFLAMMATORY AGENTS, ANTIPYRETICS, ANTIARTHRITIC AGENT HEXACHIMIE SOCIETE ANONYME (FR) 1979-08-28 US disclosed