SCHEMBL28247393

SCHEMBL28247393

CC(C)(C)OC(=O)Nc1ncc(-c2ccncc2)s1

nearest known ligand 0.49

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
LIMK1 P53667 1/20 0.49
CYP17A1 P05093 3/20 0.47
KDR P35968 2/20 0.47
KDM4E B2RXH2 1/20 0.46
ALDH1A1 P00352 1/20 0.46
GAA P10253 1/20 0.46
HPGD P15428 1/20 0.46
HSD17B10 Q99714 1/20 0.46
RCE1 Q9Y256 1/20 0.46
GSTO1 P78417 1/20 0.44
FFAR2 O15552 1/20 0.44
CSNK2A2 P19784 1/20 0.44
CSNK2A1 P68400 1/20 0.44
CCNE1 P24864 1/20 0.43
CDK2 P24941 1/20 0.43
CDK5 Q00535 1/20 0.43
SCD O00767 1/20 0.43
LCK P06239 1/20 0.43
GPR142 Q7Z601 1/20 0.43
SMN1; SMN2 Q16637 1/20 0.43

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28014843 0.88 KDR (0.62) KDRGSTO1FFAR2CSNK2A2CSNK2A1
SCHEMBL25319444 0.86 ABL1 (0.55) KDRALDH1A1GSTO1FFAR2CSNK2A2
SCHEMBL17580713 0.84 LIMK1 (0.40) LIMK1CYP17A1CSNK2A2CSNK2A1CCNE1
SCHEMBL28518148 0.83 LIMK1 (0.51) LIMK1KDRCCNE1CDK2LCK
SCHEMBL3176327 0.82 LIMK1 (0.52) LIMK1KDRKDM4EGSTO1FFAR2
SCHEMBL27930246 0.82 XDH (0.45) KDRALDH1A1CSNK2A2CSNK2A1SMN1; SMN2
SCHEMBL16513227 0.82 LIMK1 (0.46) LIMK1CYP17A1KDM4EHPGDCCNE1
SCHEMBL22684973 0.82 CSNK2A2 (0.47) CYP17A1KDRKDM4EALDH1A1HPGD
SCHEMBL22685027 0.81 CSNK2A2 (0.49) KDRGSTO1FFAR2CSNK2A2CSNK2A1
SCHEMBL22684986 0.81 CSNK2A2 (0.47) KDRGSTO1FFAR2CSNK2A2CSNK2A1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108699035-A Noval chemical compound 特殊治疗有限公司 2018-10-23 CN disclosed