SCHEMBL28247459

SCHEMBL28247459

O=CN1CCc2cc(Br)ccc21

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SLC22A12 Q96S37 1/20 0.43
SRD5A1 P18405 3/20 0.43
ABHD6 Q9BV23 1/20 0.43
ROCK1 Q13464 1/20 0.42
TUBB4A P04350 1/20 0.41
TUBB P07437 1/20 0.41
TUBA3C P0DPH7 1/20 0.41
TUBA1B P68363 1/20 0.41
TUBA4A P68366 1/20 0.41
TUBB4B P68371 1/20 0.41
TUBB3 Q13509 1/20 0.41
TUBB2A Q13885 1/20 0.41
TUBB8 Q3ZCM7 1/20 0.41
TUBA3E Q6PEY2 1/20 0.41
TUBA1A Q71U36 1/20 0.41
TUBA1C Q9BQE3 1/20 0.41
TUBB6 Q9BUF5 1/20 0.41
TUBB2B Q9BVA1 1/20 0.41
TUBB1 Q9H4B7 1/20 0.41
PDK1 Q15118 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL27675309 0.82 SRD5A1 (0.43) SLC22A12SRD5A1ABHD6ROCK1TUBB4A
SCHEMBL10267244 0.79 NOTUM (0.54) SRD5A1PDK1PDK2PDK3PDK4
SCHEMBL15528799 0.79 NOTUM (0.53) SRD5A1ROCK1HDAC1HDAC6HTR2A
SCHEMBL14626154 0.75 NOTUM (0.57) SRD5A1TUBB4ATUBBTUBA3CTUBA1B
SCHEMBL14626053 0.75 HTR2C (0.45) SMN1; SMN2HTR2AHTR2CMEN1ALDH1A1
SCHEMBL24061453 0.75 CYP11B1 (0.48) SRD5A1PARP10PARP11SMN1; SMN2HTR2A
SCHEMBL9901142 0.75 HDAC1 (0.43) SLC22A12SRD5A1ABHD6ROCK1TUBB4A
SCHEMBL14626050 0.73 CA1 (0.53) ROCK1MEN1ALDH1A1GAAMAPT
SCHEMBL2075108 0.73 POLB (0.39) ROCK1SMN1; SMN2MEN1MAPTKMT2A
SCHEMBL31687156 0.73 POLB (0.39) ROCK1SMN1; SMN2MEN1MAPTKMT2A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108699035-A Noval chemical compound 特殊治疗有限公司 2018-10-23 CN disclosed