SCHEMBL27675309

SCHEMBL27675309

C[CH]N1CCc2cc(Br)ccc21

nearest known ligand 0.43

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
SRD5A1 P18405 1/20 0.43
ROCK1 Q13464 1/20 0.42
TUBB4A P04350 1/20 0.41
TUBB P07437 1/20 0.41
TUBA3C P0DPH7 1/20 0.41
TUBA1B P68363 1/20 0.41
TUBA4A P68366 1/20 0.41
TUBB4B P68371 1/20 0.41
TUBB3 Q13509 1/20 0.41
TUBB2A Q13885 1/20 0.41
TUBB8 Q3ZCM7 1/20 0.41
TUBA3E Q6PEY2 1/20 0.41
TUBA1A Q71U36 1/20 0.41
TUBA1C Q9BQE3 1/20 0.41
TUBB6 Q9BUF5 1/20 0.41
TUBB2B Q9BVA1 1/20 0.41
TUBB1 Q9H4B7 1/20 0.41
SLC22A12 Q96S37 1/20 0.40
ABHD6 Q9BV23 1/20 0.40
CYP1A2 P05177 1/20 0.39

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL28247459 0.82 SLC22A12 (0.43) SRD5A1ROCK1TUBB4ATUBBTUBA3C
SCHEMBL27669526 0.79 ATAD2 (0.44) HTR2APDK1PDK2PDK3PDK4
SCHEMBL17351956 0.76 SRD5A1 (0.46) SRD5A1ROCK1TUBB4ATUBBTUBA3C
SCHEMBL2056315 0.76 SRD5A1 (0.46) SRD5A1ROCK1TUBB4ATUBBTUBA3C
SCHEMBL18373702 0.73 ROCK1 (0.46) SRD5A1ROCK1TUBB4ATUBBTUBA3C
SCHEMBL1198901 0.73 ALDH1A1 (0.50) LMNAMEN1NPC1KMT2A
SCHEMBL12905290 0.73 SRD5A1 (0.44) SRD5A1ROCK1TUBB4ATUBBTUBA3C
SCHEMBL28750647 0.72 PNMT (0.36) SRD5A1ROCK1TUBB4ATUBBTUBA3C
SCHEMBL13068171 0.72 ROCK1 (0.49) SRD5A1ROCK1TUBB4ATUBBTUBA3C
SCHEMBL12509817 0.71 HSD17B3 (0.55) SRD5A1ROCK1TUBB4ATUBBTUBA3C

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-101006076-B Modulators of ATP-binding cassette transporters VERTEX PHARMA 2010-09-29 CN disclosed
CN-101006076-A Modulators of ATP-binding cassette transporters VERTEX PHARMA (US) 2007-07-25 CN disclosed