Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.48 |
| ▸ | MEN1 | O00255 | 2/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.48 |
| ▸ | POLB | P06746 | 2/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
| ▸ | APP | P05067 | 3/20 | 0.45 |
| ▸ | HPGD | P15428 | 2/20 | 0.45 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.45 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.45 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.45 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.44 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.44 |
| ▸ | TP53 | P04637 | 1/20 | 0.43 |
| ▸ | ALOX15 | P16050 | 1/20 | 0.43 |
| ▸ | GLA | P06280 | 1/20 | 0.43 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.43 |
| ▸ | ATM | Q13315 | 1/20 | 0.42 |
| ▸ | SLC29A1 | Q99808 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3334146 | 0.81 | NPSR1 (0.61) | MEN1KMT2APOLBHPGDNPSR1 | |
| SCHEMBL24270053 | 0.80 | NPSR1 (0.47) | SMN1; SMN2HSD17B10MEN1KMT2APOLB | |
| SCHEMBL2822691 | 0.80 | SMN1; SMN2 (0.59) | SMN1; SMN2HSD17B10MEN1KMT2APOLB | |
| SCHEMBL8441577 | 0.80 | SMN1; SMN2 (0.59) | SMN1; SMN2HSD17B10MEN1KMT2APOLB | |
| SCHEMBL8441019 | 0.80 | SMN1; SMN2 (0.62) | SMN1; SMN2HSD17B10MEN1KMT2APOLB | |
| SCHEMBL1814092 | 0.78 | KDM4E (0.44) | HSD17B10POLBLMNAALDH1A1KDM4E | |
| SCHEMBL2824882 | 0.78 | HPGD (0.42) | HSD17B10MEN1KMT2APOLBLMNA | |
| SCHEMBL2824525 | 0.75 | KMT2A (0.42) | HSD17B10MEN1KMT2APOLBALDH1A1 | |
| SCHEMBL2279408 | 0.75 | NPC1 (0.40) | SMN1; SMN2HSD17B10MEN1KMT2ALMNA | |
| SCHEMBL14573266 | 0.73 | CD274 (0.62) | POLBHPGDCYP1A2CYP2D6ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2196465-A1 | (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2010-06-16 | — | — | EP | disclosed |
| EP-2196465-A1 | (3-oxo)pyridazin-4-ylurea derivatives as PDE4 inhibitors | Almirall, S.A. (ES) | 2010-06-16 | — | — | EP | disclosed |