Known targets — ChEMBL curated mechanism
ADORA1ADORA2AADORA2BADORA3PDE3APDE3BPDE4APDE4BPDE4CPDE4D
The experimentally established mechanism targets of Glycine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TSHR | P16473 | 3/20 | 0.48 |
| ▸ | GLRA1 | P23415 | 1/20 | 0.36 |
| ▸ | SLC6A9 | P48067 | 1/20 | 0.36 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.36 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.33 |
| ▸ | CACNA2D1 | P54289 | 2/20 | 0.32 |
| ▸ | CACNB3 | P54284 | 1/20 | 0.32 |
| ▸ | CACNA1C | Q13936 | 1/20 | 0.32 |
| ▸ | PGR | P06401 | 1/20 | 0.32 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.32 |
| ▸ | HTR2B | P41595 | 1/20 | 0.32 |
| ▸ | CACNA2D2 | Q9NY47 | 1/20 | 0.32 |
| ▸ | MAP3K7 | O43318 | 1/20 | 0.31 |
| ▸ | TAB1 | Q15750 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL1473218 | 0.89 | TSHR (0.59) | TSHRALDH1A1MAP3K7TAB1HPGD | |
| SCHEMBL873046 | 0.89 | TSHR (0.59) | TSHRALDH1A1MAP3K7TAB1HPGD | |
| SCHEMBL873047 | 0.89 | TSHR (0.59) | TSHRALDH1A1MAP3K7TAB1HPGD | |
| SCHEMBL10799068 | 0.77 | TSHR (0.47) | TSHRALDH1A1HPGD | |
| SCHEMBL28250022 | 0.76 | ALOX15 (0.46) | TSHRALDH1A1PGRHPGDRAB9A | |
| SCHEMBL30136469 | 0.76 | TSHR (0.42) | TSHRRAB9A | |
| SCHEMBL30282034 | 0.76 | TSHR (0.42) | TSHRRAB9A | |
| SCHEMBL7932628 | 0.76 | TSHR (0.44) | TSHR | |
| SCHEMBL29557799 | 0.76 | TSHR (0.53) | TSHRALDH1A1MAP3K7TAB1HPGD | |
| SCHEMBL29558246 | 0.76 | TSHR (0.53) | TSHRALDH1A1MAP3K7TAB1HPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108740701-B | Bitter inhibitor | 长冈香料株式会社 | 2019-07-23 | — | — | CN | disclosed |
| CN-108740701-A | Bitter inhibitor | 长冈香料株式会社 | 2018-11-06 | — | — | CN | disclosed |