Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.55 |
| ▸ | NPC1 | O15118 | 1/20 | 0.55 |
| ▸ | LMNA | P02545 | 1/20 | 0.55 |
| ▸ | RAB9A | P51151 | 1/20 | 0.55 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.55 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.55 |
| ▸ | TP53 | P04637 | 1/20 | 0.55 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.50 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.50 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.50 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.50 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.50 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.50 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclopropane SCHEMBL2825655 | 0.92 | MAPT (0.53) | MAPTNPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL2828040 | 0.90 | MAPT (0.55) | MAPTNPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL2823265 | 0.90 | MAPT (0.57) | MAPTNPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL2825532 | 0.90 | MAPT (0.54) | MAPTNPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL2825724 | 0.89 | MAPT (0.56) | MAPTNPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL2828235 | 0.89 | MAPT (0.56) | MAPTNPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL2024771 | 0.89 | MAPT (0.69) | MAPTNPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL2825087 | 0.88 | MAPT (0.57) | MAPTNPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL2030793 | 0.88 | MAPT (0.67) | MAPTNPC1LMNARAB9ASMN1; SMN2 | |
| SCHEMBL2027232 | 0.88 | MAPT (0.67) | MAPTNPC1LMNARAB9ASMN1; SMN2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1791543-B1 | TRIAZOLOPHTHALAZINES | NYCOMED GMBH (DE) | 2010-06-16 | — | — | EP | claimed |