Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.53 |
| ▸ | NPSR1 | Q6W5P4 | 2/20 | 0.53 |
| ▸ | NPC1 | O15118 | 1/20 | 0.53 |
| ▸ | LMNA | P02545 | 1/20 | 0.53 |
| ▸ | RAB9A | P51151 | 1/20 | 0.53 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.53 |
| ▸ | TP53 | P04637 | 1/20 | 0.53 |
| ▸ | POLB | P06746 | 2/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.48 |
| ▸ | GABRA1 | P14867 | 4/20 | 0.48 |
| ▸ | GABRG2 | P18507 | 4/20 | 0.48 |
| ▸ | GABRB3 | P28472 | 4/20 | 0.48 |
| ▸ | GABRA5 | P31644 | 4/20 | 0.48 |
| ▸ | GABRA3 | P34903 | 4/20 | 0.48 |
| ▸ | GABRA2 | P47869 | 4/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Cyclopropane SCHEMBL2824876 | 0.92 | MAPT (0.55) | MAPTNPSR1NPC1LMNARAB9A | |
| SCHEMBL2827889 | 0.91 | MAPT (0.61) | MAPTNPSR1NPC1LMNARAB9A | |
| SCHEMBL2828301 | 0.91 | POLB (0.60) | MAPTNPSR1NPC1LMNARAB9A | |
| SCHEMBL2828630 | 0.90 | MAPT (0.57) | MAPTNPSR1NPC1LMNARAB9A | |
| SCHEMBL2829203 | 0.88 | MAPT (0.52) | MAPTNPSR1NPC1LMNARAB9A | |
| SCHEMBL2856247 | 0.88 | MAPT (0.52) | MAPTNPSR1NPC1LMNARAB9A | |
| SCHEMBL2827797 | 0.88 | GABRA1 (0.52) | MAPTNPSR1NPC1LMNARAB9A | |
| SCHEMBL2828708 | 0.88 | MAPT (0.51) | MAPTNPSR1NPC1LMNARAB9A | |
| SCHEMBL2828885 | 0.88 | MAPT (0.51) | MAPTNPSR1NPC1LMNARAB9A | |
| SCHEMBL2851345 | 0.88 | MAPT (0.55) | MAPTNPSR1NPC1LMNARAB9A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1791543-B1 | TRIAZOLOPHTHALAZINES | NYCOMED GMBH (DE) | 2010-06-16 | — | — | EP | claimed |