Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK11 | Q15759 | 2/20 | 0.53 |
| ▸ | MAPK14 | Q16539 | 2/20 | 0.53 |
| ▸ | CYP11B2 | P19099 | 4/20 | 0.43 |
| ▸ | CYP11B1 | P15538 | 3/20 | 0.43 |
| ▸ | KDM5A | P29375 | 1/20 | 0.41 |
| ▸ | CYP2C19 | P33261 | 3/20 | 0.41 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.41 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.41 |
| ▸ | TSHR | P16473 | 1/20 | 0.41 |
| ▸ | GSK3B | P49841 | 1/20 | 0.41 |
| ▸ | LMNA | P02545 | 1/20 | 0.41 |
| ▸ | CYP2C9 | P11712 | 2/20 | 0.40 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.40 |
| ▸ | HTT | P42858 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.40 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.40 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.40 |
| ▸ | IKBKB | O14920 | 1/20 | 0.40 |
| ▸ | NPC1 | O15118 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL18965247 | 0.79 | MAPK14 (0.48) | MAPK11MAPK14KDM5AGSK3B | |
| SCHEMBL20772280 | 0.78 | TP53 (0.70) | LMNAHTTTP53 | |
| SCHEMBL2100499 | 0.78 | TP53 (0.60) | MAPK11MAPK14CYP2C19CYP1A2CYP2D6 | |
| SCHEMBL28257968 | 0.77 | IDO1 (0.43) | MAPK11MAPK14LMNAHTTMAPK1 | |
| SCHEMBL5173417 | 0.76 | — | — | |
| SCHEMBL29597773 | 0.76 | — | — | |
| SCHEMBL19658655 | 0.76 | MAPK11 (0.53) | MAPK11MAPK14KDM5ATSHRGSK3B | |
| SCHEMBL28254346 | 0.73 | PRCP (0.40) | MAPK11MAPK14KDM5A | |
| SCHEMBL5172903 | 0.73 | MAP4K4 (0.43) | CYP11B2KDM5ACYP2C19CYP1A2CYP2D6 | |
| SCHEMBL3200493 | 0.73 | CAMKK2 (0.44) | CYP11B2KDM5ACYP2C19CYP1A2CYP2D6 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105473576-B | Pyrimidinedione compounds for cardiac disorders | 迈奥卡迪亚公司 | 2018-10-30 | — | — | CN | disclosed |