Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 19/20 | 0.61 |
| ▸ | PIK3R1 | P27986 | 10/20 | 0.61 |
| ▸ | MTOR | P42345 | 6/20 | 0.56 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.56 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.52 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.51 |
| ▸ | JAK3 | P52333 | 2/20 | 0.49 |
| ▸ | RICTOR | Q6R327 | 2/20 | 0.48 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.48 |
| ▸ | MAPKAP1 | Q9BPZ7 | 2/20 | 0.48 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.48 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.48 |
| ▸ | JAK2 | O60674 | 1/20 | 0.48 |
| ▸ | JAK1 | P23458 | 1/20 | 0.48 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7917254 | 0.81 | PIK3CA (0.58) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| SCHEMBL8062292 | 0.79 | PIK3CA (0.58) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| SCHEMBL12006072 | 0.76 | PIK3CA (1.00) | PIK3CAPIK3R1MTORPIK3CDJAK3 | |
| SCHEMBL10327870 | 0.76 | PIK3CA (0.68) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| SCHEMBL1655495 | 0.74 | PIK3CA (0.58) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| SCHEMBL18032475 | 0.74 | PIK3CA (0.57) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| SCHEMBL10328269 | 0.73 | PIK3CA (0.64) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| SCHEMBL1308957 | 0.73 | PIK3CA (1.00) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| SCHEMBL2565055 | 0.73 | PIK3CA (0.51) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| SCHEMBL18383735 | 0.73 | PIK3CA (0.63) | PIK3CAPIK3R1MTORPIK3CDPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20100324284-A1 | PYRROLOPYRIMIDINE DERIVATIVE AS P13K INHIBITOR AND USE THEREOF | CHUGAI SEIYAKU KABUSHIKI KAISHA | 2010-12-23 | — | — | US | disclosed |
| US-20100324284-A1 | PYRROLOPYRIMIDINE DERIVATIVE AS P13K INHIBITOR AND USE THEREOF | CHUGAI SEIYAKU KABUSHIKI KAISHA | 2010-12-23 | — | — | US | disclosed |
| EP-2239261-A1 | PYRROLOPYRIMIDIN DERIVATIVE FOR USE AS PI3K INHIBITOR, AND USE THEREOF | Chugai Seiyaku Kabushiki Kaisha (JP) | 2010-10-13 | — | — | EP | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100324284-A1 | PYRROLOPYRIMIDINE DERIVATIVE AS P13K INHIBITOR AND USE THEREOF | CSNK1A1, CSK, CSNK1A1L | PIK3CA 44/4885PIK3R1 69/4885MTOR 12/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.