Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIK3CA | P42336 | 20/20 | 0.58 |
| ▸ | PIK3R1 | P27986 | 11/20 | 0.58 |
| ▸ | MTOR | P42345 | 6/20 | 0.58 |
| ▸ | PIK3CD | O00329 | 4/20 | 0.55 |
| ▸ | PIK3CB | P42338 | 3/20 | 0.55 |
| ▸ | PIK3CG | P48736 | 2/20 | 0.55 |
| ▸ | JAK2 | O60674 | 1/20 | 0.55 |
| ▸ | JAK1 | P23458 | 1/20 | 0.55 |
| ▸ | JAK3 | P52333 | 1/20 | 0.55 |
| ▸ | MAP3K12 | Q12852 | 1/20 | 0.52 |
| ▸ | RICTOR | Q6R327 | 2/20 | 0.49 |
| ▸ | RPTOR | Q8N122 | 2/20 | 0.49 |
| ▸ | MAPKAP1 | Q9BPZ7 | 2/20 | 0.49 |
| ▸ | MLST8 | Q9BVC4 | 2/20 | 0.49 |
| ▸ | PIK3C2B | O00750 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8079836 | 0.88 | PIK3CA (0.59) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| SCHEMBL7952861 | 0.82 | PIK3CA (0.58) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| SCHEMBL30677407 | 0.81 | GAA (0.47) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| SCHEMBL14249567 | 0.81 | PIK3CA (0.46) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| SCHEMBL14316117 | 0.80 | CNR2 (0.44) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| SCHEMBL31748485 | 0.79 | SRC (0.47) | PIK3CAPIK3R1MTOR | |
| SCHEMBL2825498 | 0.79 | PIK3CA (0.61) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| SCHEMBL1568626 | 0.78 | PIK3CA (0.65) | PIK3CAMTORPIK3CG | |
| SCHEMBL7917254 | 0.78 | PIK3CA (0.58) | PIK3CAPIK3R1MTORPIK3CDPIK3CB | |
| SCHEMBL12537215 | 0.78 | ATR (0.49) | PIK3CAPIK3R1MTORPIK3CG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20140066620-A1 | PYRIMIDINE SUBSTITUTED PURINE DERIVATIVES | VERASTEM, INC. (US) | 2014-03-06 | — | — | US | disclosed |
| US-20140066620-A1 | PYRIMIDINE SUBSTITUTED PURINE DERIVATIVES | VERASTEM, INC. (US) | 2014-03-06 | — | — | US | disclosed |
| US-20130079512-A1 | PYRIMIDINE SUBSTITUTED PURINE DERIVATIVES | Verastem (US) | 2013-03-28 | — | — | US | disclosed |
| US-20130079512-A1 | PYRIMIDINE SUBSTITUTED PURINE DERIVATIVES | Verastem (US) | 2013-03-28 | — | — | US | disclosed |
| EP-2209786-B1 | PYRIMIDINE SUBSTITUTED PURINE DERIVATIVES | VERASTEM INC (US) | 2013-02-27 | — | — | EP | disclosed |
| US-8247410-B2 | Pyrimidine substituted purine derivatives | Verastem (US) | 2012-08-21 | — | — | US | disclosed |
| US-8247410-B2 | Pyrimidine substituted purine derivatives | Verastem (US) | 2012-08-21 | — | — | US | disclosed |
| US-20100298319-A1 | PYRIMIDINE SUBSTITUTED PURINE DERIVATIVES | S*BIO PTE LTD. (SG) | 2010-11-25 | — | — | US | disclosed |
| US-20100298319-A1 | PYRIMIDINE SUBSTITUTED PURINE DERIVATIVES | S*BIO PTE LTD. (SG) | 2010-11-25 | — | — | US | disclosed |
| WO-2009045175-A1 | PYRIMIDINE SUBSTITUTED PURINE DERIVATIVES | S*BIO PTE LTD (SG) | 2009-04-09 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (3 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20140066620-A1 | PYRIMIDINE SUBSTITUTED PURINE DERIVATIVES | TYMP, PIK3CA, PNP | PIK3CA 2/4885PIK3R1 153/4885MTOR 7/4885 |
| US-20100298319-A1 | PYRIMIDINE SUBSTITUTED PURINE DERIVATIVES | TYMP, PIK3CA, PNP | PIK3CA 2/4885PIK3R1 153/4885MTOR 7/4885 |
| US-20130079512-A1 | PYRIMIDINE SUBSTITUTED PURINE DERIVATIVES | TYMP, PIK3CA, PNP | PIK3CA 2/4885PIK3R1 153/4885MTOR 7/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.