Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Phosphine. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.48 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.48 |
| ▸ | TSHR | P16473 | 1/20 | 0.48 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.48 |
| ▸ | SNCA | P37840 | 2/20 | 0.38 |
| ▸ | CHRNA7 | P36544 | 8/20 | 0.36 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.36 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.35 |
| ▸ | TP53 | P04637 | 1/20 | 0.35 |
| ▸ | LMNA | P02545 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL28290559 | 0.98 | HIF1A (0.61) | HIF1AALDH1A1CYP1A2CYP2D6TSHR | |
| Bromide SCHEMBL164032 | 0.98 | HIF1A (0.67) | HIF1AALDH1A1CYP1A2CYP2D6TSHR | |
| Bromide SCHEMBL30583946 | 0.98 | HIF1A (0.67) | HIF1AALDH1A1CYP1A2CYP2D6TSHR | |
| SCHEMBL29421497 | 0.95 | HIF1A (0.70) | HIF1AALDH1A1CYP1A2CYP2D6TSHR | |
| Bromide SCHEMBL4596472 | 0.93 | HIF1A (0.61) | HIF1AALDH1A1CYP1A2CYP2D6TSHR | |
| Water SCHEMBL3418016 | 0.93 | HIF1A (0.67) | HIF1AALDH1A1CYP1A2CYP2D6TSHR | |
| Hydrochloric Acid SCHEMBL2039214 | 0.93 | HIF1A (0.67) | HIF1AALDH1A1CYP1A2CYP2D6TSHR | |
| Iodide SCHEMBL297568 | 0.93 | HIF1A (0.67) | HIF1AALDH1A1CYP1A2CYP2D6TSHR | |
| Fluoride Ion SCHEMBL31171038 | 0.93 | HIF1A (0.67) | HIF1AALDH1A1CYP1A2CYP2D6TSHR | |
| SCHEMBL7865520 | 0.91 | HIF1A (0.64) | HIF1AALDH1A1CYP1A2CYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108910867-A | A kind of method of MPCVD preparation doping nitrogen phosphorus graphene | 恒力（厦门）石墨烯科技产业集团有限公司 | 2018-11-30 | — | — | CN | claimed |