Known targets — ChEMBL curated mechanism
ACHECHKACHRM1CHRM2CHRM3CHRM4CHRM5CHRNA1CHRNB1CHRNDCHRNECHRNGHRH2OPRM1
The experimentally established mechanism targets of Bromide. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HIF1A | Q16665 | 1/20 | 0.61 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.47 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.47 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.47 |
| ▸ | SNCA | P37840 | 2/20 | 0.37 |
| ▸ | CHRNA7 | P36544 | 8/20 | 0.35 |
| ▸ | TRAP1 | Q12931 | 2/20 | 0.35 |
| ▸ | AOC3 | Q16853 | 1/20 | 0.34 |
| ▸ | TP53 | P04637 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Bromide SCHEMBL164032 | 0.95 | HIF1A (0.67) | HIF1AALDH1A1CYP1A2CYP2D6TSHR | |
| Bromide SCHEMBL30583946 | 0.95 | HIF1A (0.67) | HIF1AALDH1A1CYP1A2CYP2D6TSHR | |
| Phosphine SCHEMBL28255446 | 0.93 | HIF1A (0.64) | HIF1AALDH1A1CYP1A2CYP2D6TSHR | |
| SCHEMBL29421497 | 0.93 | HIF1A (0.70) | HIF1AALDH1A1CYP1A2CYP2D6TSHR | |
| Bromide SCHEMBL28290559 | 0.91 | HIF1A (0.61) | HIF1AALDH1A1CYP1A2CYP2D6TSHR | |
| Hydrochloric Acid SCHEMBL2039214 | 0.91 | HIF1A (0.67) | HIF1AALDH1A1CYP1A2CYP2D6TSHR | |
| Water SCHEMBL3418016 | 0.91 | HIF1A (0.67) | HIF1AALDH1A1CYP1A2CYP2D6TSHR | |
| Fluoride Ion SCHEMBL31171038 | 0.91 | HIF1A (0.67) | HIF1AALDH1A1CYP1A2CYP2D6TSHR | |
| Iodide SCHEMBL297568 | 0.91 | HIF1A (0.67) | HIF1AALDH1A1CYP1A2CYP2D6TSHR | |
| SCHEMBL7865520 | 0.88 | HIF1A (0.64) | HIF1AALDH1A1CYP1A2CYP2D6TSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7414043-B2 | 9-α-substituted estratrienes as selectively active estrogens | SCHERING AG (DE) | 2008-08-19 | — | — | US | disclosed |
| US-20080132476-A1 | SUBSTITUTED ESTRATRIENES AS SELECTIVELY ACTIVE ESTROGENS | KOSEMUND DIRK | 2008-06-05 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20080132476-A1 | SUBSTITUTED ESTRATRIENES AS SELECTIVELY ACTIVE ESTROGENS | ESRRA, ESR2, ESR1 | HIF1A 3440/4885ALDH1A1 255/4885CYP1A2 196/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.