⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL21883265 | 0.76 | — | — | |
| SCHEMBL2366380 | 0.70 | — | — | |
| SCHEMBL2366362 | 0.70 | — | — | |
| SCHEMBL1063161 | 0.70 | — | — | |
| SCHEMBL3949978 | 0.70 | — | — | |
| SCHEMBL20091108 | 0.65 | — | — | |
| SCHEMBL20711460 | 0.65 | — | — | |
| SCHEMBL8631889 | 0.65 | LMNA (0.34) | — | |
| SCHEMBL7093979 | 0.65 | — | — | |
| SCHEMBL7090530 | 0.65 | — | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 10 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2948461-A1 | COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS | Entasis Therapeutics Limited (GB) | 2015-12-02 | — | — | EP | claimed |
| WO-2014114929-A1 | COMPOUNDS AND METHODS FOR TREATING BACTERIAL INFECTIONS | ASTRAZENECA AB (SE) | 2014-07-31 | — | — | WO | claimed |
| EP-1937688-B1 | IMIDAZO BENZODIAZEPINE DERIVATIVES | HOFFMANN LA ROCHE (CH) | 2010-08-11 | — | — | EP | disclosed |
| US-7507729-B2 | for the treatment of cognitive disorders, anxiety, schizophrenia, and Alzheimer's disease; ligands; GABA A alpha 5 receptor inhibitors; 3-bromo-10-chloro-6-(2-oxo-pyrrolidin-1-ylmethyl)-9H-imidazo[1,5-a][1,2,4]triazolo[1,5-d][1,4]benzodiazepine | HOFFMANN-LA ROCHE INC. (US) | 2009-03-24 | — | — | US | disclosed |
| EP-1937688-A1 | IMIDAZO BENZODIAZEPINE DERIVATIVES | F.HOFFMANN-LA ROCHE AG (CH) | 2008-07-02 | — | — | EP | disclosed |
| WO-2007042421-A1 | IMIDAZO BENZODIAZEPINE DERIVATIVES | F. HOFFMANN-LA ROCHE AG (CH) | 2007-04-19 | — | — | WO | disclosed |
| US-20070082890-A1 | Substituted imidazo-[1,5-a][1,2,4]triazolo[1,5-d][1,4] benzodiazepine derivatives | BANK OF AMERICA, N.A., AS ADMINISTRATIVE AGENT | 2007-04-12 | — | — | US | disclosed |
| EP-0206318-B1 | ORGANOPHOSPHORUS COMPOUNDS, PROCESS FOR THEIR PREPARATION AND INSECTICIDAL, MITICIDAL, NEMATICIDAL OR SOIL PESTICIDAL COMPOSITIONS CONTAINING THEM | ISHIHARA SANGYO KAISHA, LTD. (JP) | 1990-04-11 | — | — | EP | disclosed |
| US-4783451-A | Organophosphorus, compounds and insecticidal, miticidal, nematicidal or soil pesticidal compositions containing them | ISHIHARA SANGYO KAISHA LTD. (JP) | 1988-11-08 | — | — | US | disclosed |
| EP-0206318-A2 | Organophosphorus compounds, process for their preparation and insecticidal, miticidal, nematicidal or soil pesticidal compositions containing them | ISHIHARA SANGYO KAISHA, LTD. (JP) | 1986-12-30 | — | — | EP | disclosed |