Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PIM1 | P11309 | 1/20 | 0.45 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.45 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | HPGD | P15428 | 1/20 | 0.41 |
| ▸ | MAPT | P10636 | 1/20 | 0.40 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.40 |
| ▸ | NPSR1 | Q6W5P4 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.40 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.40 |
| ▸ | ATM | Q13315 | 1/20 | 0.40 |
| ▸ | BTK | Q06187 | 9/20 | 0.39 |
| ▸ | RAB9A | P51151 | 1/20 | 0.39 |
| ▸ | CFTR | P13569 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28258704 | 0.83 | PIM1 (0.44) | PIM1PIM3ALDH1A1KDM4EMAPT | |
| SCHEMBL11386891 | 0.81 | KDM4E (0.44) | ALDH1A1KDM4EHPGDMAPK1DYRK1A | |
| SCHEMBL8573302 | 0.79 | MEN1 (0.63) | PIM1PIM3ALDH1A1KDM4EHPGD | |
| SCHEMBL27982582 | 0.78 | PIM1 (0.49) | PIM1PIM3ALDH1A1JAK2DYRK1A | |
| SCHEMBL28054157 | 0.77 | PIM1 (0.46) | PIM1PIM3ALDH1A1JAK2DYRK1A | |
| SCHEMBL28058578 | 0.75 | PIM1 (0.44) | PIM1PIM3ALDH1A1JAK2DYRK1A | |
| SCHEMBL28018016 | 0.75 | DYRK1A (0.52) | PIM1PIM3ALDH1A1KDM4EMAPT | |
| SCHEMBL27982171 | 0.73 | PIM1 (0.41) | PIM1PIM3ALDH1A1JAK2DYRK1A | |
| SCHEMBL28260173 | 0.72 | PIM1 (0.43) | PIM1PIM3ALDH1A1KDM4EMAPT | |
| SCHEMBL28258739 | 0.71 | PIM1 (0.48) | PIM1PIM3ALDH1A1KDM4EHPGD |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105008352-B | Carbazole compounds useful as bromodomain inhibitors | 百时美施贵宝公司 | 2018-12-07 | — | — | CN | disclosed |