Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 3/20 | 0.63 |
| ▸ | MAPT | P10636 | 3/20 | 0.63 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.63 |
| ▸ | PIM1 | P11309 | 1/20 | 0.50 |
| ▸ | PIM3 | Q86V86 | 1/20 | 0.50 |
| ▸ | KIF11 | P52732 | 1/20 | 0.47 |
| ▸ | ALDH1A1 | P00352 | 2/20 | 0.45 |
| ▸ | ATM | Q13315 | 1/20 | 0.45 |
| ▸ | PARP1 | P09874 | 2/20 | 0.45 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.44 |
| ▸ | JAK2 | O60674 | 1/20 | 0.44 |
| ▸ | BTK | Q06187 | 5/20 | 0.43 |
| ▸ | CHEK1 | O14757 | 1/20 | 0.41 |
| ▸ | PRKCA | P17252 | 3/20 | 0.41 |
| ▸ | MAP2 | P11137 | 1/20 | 0.41 |
| ▸ | PRKD3 | O94806 | 1/20 | 0.41 |
| ▸ | CCNB2 | O95067 | 1/20 | 0.41 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.41 |
| ▸ | PRKCG | P05129 | 1/20 | 0.41 |
| ▸ | PRKCB | P05771 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28258739 | 0.82 | PIM1 (0.48) | MEN1MAPTKMT2APIM1PIM3 | |
| SCHEMBL28018016 | 0.80 | DYRK1A (0.52) | MEN1MAPTKMT2APIM1PIM3 | |
| SCHEMBL28258673 | 0.79 | PIM1 (0.45) | MAPTPIM1PIM3ALDH1A1ATM | |
| SCHEMBL30007474 | 0.79 | KIF11 (0.51) | MEN1MAPTKMT2APIM1PIM3 | |
| SCHEMBL1603150 | 0.78 | MAPT (1.00) | MEN1MAPTKMT2AKIF11ALDH1A1 | |
| SCHEMBL29402096 | 0.78 | MAPT (1.00) | MEN1MAPTKMT2AKIF11ALDH1A1 | |
| SCHEMBL28258704 | 0.78 | PIM1 (0.44) | MEN1MAPTKMT2APIM1PIM3 | |
| SCHEMBL28260173 | 0.77 | PIM1 (0.43) | MEN1MAPTKMT2APIM1PIM3 | |
| SCHEMBL11741897 | 0.77 | MAPT (0.65) | MEN1MAPTKMT2AKIF11ALDH1A1 | |
| SCHEMBL16240951 | 0.76 | DYRK1A (0.52) | PIM1PIM3KIF11ALDH1A1ATM |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105008352-B | Carbazole compounds useful as bromodomain inhibitors | 百时美施贵宝公司 | 2018-12-07 | — | — | CN | claimed |
| CN-105008352-B | Carbazole compounds useful as bromodomain inhibitors | 百时美施贵宝公司 | 2018-12-07 | — | — | CN | disclosed |
| WO-1998018464-A1 | SUBSTITUTED TRICYCLICS | ELI LILLY AND COMPANY (US) | 1998-05-07 | — | — | WO | disclosed |