SCHEMBL28259186

SCHEMBL28259186

CSCCNCc1c[c]ccn1

nearest known ligand 0.35

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
SIRT2 Q8IXJ6 4/20 0.35
CHRM2 P08172 1/20 0.33

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL4862018 0.75
SCHEMBL295224 0.75
SCHEMBL16292980 0.74 CHRM2 (0.40) SIRT2CHRM2
SCHEMBL19583588 0.73 CHRM2 (0.62) SIRT2CHRM2
SCHEMBL6995839 0.69 ADH1B (0.34)
SCHEMBL15994154 0.69 SIRT2 (0.41) SIRT2CHRM2
SCHEMBL15994191 0.68 SIRT2 (0.41) SIRT2CHRM2
SCHEMBL739945 0.67
SCHEMBL16291634 0.66 KDM5B (0.52) SIRT2
SCHEMBL5605063 0.65 KDM4E (0.32)

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-105263906-B The inhibitor of histone demethylase 吉利德科学公司 2018-11-23 CN disclosed