Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ketotifen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 6/20 | 0.95 |
| ▸ | DRD3 | P35462 | 7/20 | 0.95 |
| ▸ | CHRM2 | P08172 | 6/20 | 0.95 |
| ▸ | CHRM1 | P11229 | 6/20 | 0.95 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.95 |
| ▸ | DRD1 | P21728 | 5/20 | 0.95 |
| ▸ | HTR2A | P28223 | 5/20 | 0.95 |
| ▸ | HTR2C | P28335 | 5/20 | 0.95 |
| ▸ | ADRA1A | P35348 | 5/20 | 0.95 |
| ▸ | KCNH2 | Q12809 | 5/20 | 0.95 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.95 |
| ▸ | LMNA | P02545 | 4/20 | 0.95 |
| ▸ | HTR2B | P41595 | 4/20 | 0.95 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.95 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.95 |
| ▸ | HTR3A | P46098 | 3/20 | 0.95 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.95 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.95 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.95 |
| ▸ | HTR6 | P50406 | 3/20 | 0.95 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ketotifen SCHEMBL3386047 | 0.99 | DRD3 (0.97) | DRD3HRH1CHRM2CHRM1ADRA2A | |
| Ketotifen SCHEMBL29356083 | 0.97 | DRD3 (1.00) | DRD3HRH1CHRM2CHRM1ADRA2A | |
| Ketotifen SCHEMBL4436 | 0.97 | DRD3 (1.00) | DRD3HRH1CHRM2CHRM1ADRA2A | |
| Ketotifen SCHEMBL223510 | 0.97 | DRD3 (1.00) | DRD3HRH1CHRM2CHRM1ADRA2A | |
| Ketotifen SCHEMBL1170804 | 0.96 | DRD3 (0.97) | DRD3HRH1CHRM2CHRM1ADRA2A | |
| Ketotifen SCHEMBL1171289 | 0.96 | DRD3 (0.97) | DRD3HRH1CHRM2CHRM1ADRA2A | |
| Ketotifen SCHEMBL1171294 | 0.93 | DRD3 (0.91) | DRD3HRH1CHRM2CHRM1ADRA2A | |
| Ketotifen SCHEMBL9060252 | 0.92 | DRD3 (0.89) | DRD3HRH1CHRM2CHRM1ADRA2A | |
| Ketotifen SCHEMBL5968240 | 0.91 | DRD3 (0.87) | DRD3HRH1CHRM2CHRM1ADRA2A | |
| Ketotifen SCHEMBL1170677 | 0.89 | DRD3 (1.00) | DRD3HRH1CHRM2CHRM1ADRA2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109069653-A | Collapsing property of speed tablet granules in oral cavity | 特华制药株式会社 | 2018-12-21 | — | — | CN | disclosed |