Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Ketotifen. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HRH1 known ✓ | P35367 | 5/20 | 0.97 |
| ▸ | DRD3 | P35462 | 7/20 | 0.97 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.97 |
| ▸ | ADRA2A | P08913 | 5/20 | 0.97 |
| ▸ | CHRM1 | P11229 | 5/20 | 0.97 |
| ▸ | DRD1 | P21728 | 5/20 | 0.97 |
| ▸ | ADRA2B | P18089 | 4/20 | 0.97 |
| ▸ | HTR2A | P28223 | 4/20 | 0.97 |
| ▸ | HTR2C | P28335 | 4/20 | 0.97 |
| ▸ | LMNA | P02545 | 4/20 | 0.97 |
| ▸ | ADRA1A | P35348 | 4/20 | 0.97 |
| ▸ | KCNH2 | Q12809 | 4/20 | 0.97 |
| ▸ | CYP2D6 | P10635 | 4/20 | 0.97 |
| ▸ | CYP2C19 | P33261 | 4/20 | 0.97 |
| ▸ | HTR3A | P46098 | 3/20 | 0.97 |
| ▸ | CHRM4 | P08173 | 3/20 | 0.97 |
| ▸ | CHRM5 | P08912 | 3/20 | 0.97 |
| ▸ | CHRM3 | P20309 | 3/20 | 0.97 |
| ▸ | HTR6 | P50406 | 3/20 | 0.97 |
| ▸ | ADRA2C | P18825 | 3/20 | 0.97 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ketotifen SCHEMBL28259803 | 0.99 | DRD3 (0.95) | DRD3HRH1CHRM2ADRA2ACHRM1 | |
| Ketotifen SCHEMBL223510 | 0.99 | DRD3 (1.00) | DRD3HRH1CHRM2ADRA2ACHRM1 | |
| Ketotifen SCHEMBL4436 | 0.99 | DRD3 (1.00) | DRD3HRH1CHRM2ADRA2ACHRM1 | |
| Ketotifen SCHEMBL29356083 | 0.99 | DRD3 (1.00) | DRD3HRH1CHRM2ADRA2ACHRM1 | |
| Ketotifen SCHEMBL1170804 | 0.97 | DRD3 (0.97) | DRD3HRH1CHRM2ADRA2ACHRM1 | |
| Ketotifen SCHEMBL1171289 | 0.97 | DRD3 (0.97) | DRD3HRH1CHRM2ADRA2ACHRM1 | |
| Ketotifen SCHEMBL1171294 | 0.94 | DRD3 (0.91) | DRD3HRH1CHRM2ADRA2ACHRM1 | |
| Ketotifen SCHEMBL9060252 | 0.93 | DRD3 (0.89) | DRD3HRH1CHRM2ADRA2ACHRM1 | |
| Ketotifen SCHEMBL5968240 | 0.92 | DRD3 (0.87) | DRD3HRH1CHRM2ADRA2ACHRM1 | |
| Ketotifen SCHEMBL1170677 | 0.90 | DRD3 (1.00) | DRD3HRH1CHRM2ADRA2ACHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1172098-B1 | Eye drop composition comprising ketotifen | NOVARTIS AG (CH) | 2010-12-15 | — | — | EP | disclosed |
| US-6776982-B2 | COMPRISES KETOTIFEN HYDROGEN FUMARAT, GLYCEROL, BENZALKONIUM CHLORIDE AND WATER; STABILITY; FOR USE IN OPHTHALMOLOGY | NOVARTIS AG (CH) | 2004-08-17 | — | — | US | disclosed |
| US-6576649-B1 | Such as storage of eye drops in antioxidant impregnated plastic bottle providing heat, light, oxygen resistance | NOVARTIS AG (CH) | 2003-06-10 | — | — | US | disclosed |
| US-6468548-B1 | STABILIZING AN OPHTHALMIC COMPOSITION COMPRISING DEXAMETHASONE OR KETOTIFEN WITH ETHYLENEDIAMINE TETRAACETIC ACID, DESFEROXAMINE, CHELATING AGENTS HAVING PHOSPHONIC ACID GROUPS, OR HAVING PHOSPHONATE GROUPS | NOVARTIS AG (CH) | 2002-10-22 | — | — | US | disclosed |
| US-6455547-B1 | STABILIZING PHARMACEUTICAL COMPOSITION BY CONTACTING WITH POLYMERIC MATERIAL CONTAINING AN ANTIOXIDANT; EYE DROPS | NOVARTIS AG (CH) | 2002-09-24 | — | — | US | disclosed |
| EP-1098649-A1 | METHOD FOR STABILIZING PHARMACEUTICAL COMPOSITIONS BY SPECIAL USE OF AN ANTIOXIDANT | Novartis AG (CH) | 2001-05-16 | — | — | EP | disclosed |
| WO-1999051230-A1 | METHOD FOR STABILIZING PHARMACEUTICAL COMPOSITIONS BY SPECIAL USE OF AN ANTIOXIDANT | NOVARTIS AG (CH) | 1999-10-14 | — | — | WO | disclosed |