Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.49 |
| ▸ | PKM | P14618 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | HTT | P42858 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.48 |
| ▸ | HRH3 | Q9Y5N1 | 6/20 | 0.47 |
| ▸ | PANK3 | Q9H999 | 4/20 | 0.45 |
| ▸ | CA12 | O43570 | 1/20 | 0.44 |
| ▸ | CA1 | P00915 | 1/20 | 0.44 |
| ▸ | CA2 | P00918 | 1/20 | 0.44 |
| ▸ | CA9 | Q16790 | 1/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | NAMPT | P43490 | 1/20 | 0.43 |
| ▸ | DGAT1 | O75907 | 2/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.43 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.43 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2825729 | 0.85 | KDM4E (0.56) | KDM4EMAPTHTTSMN1; SMN2ALDH1A1 | |
| Cyclopropane SCHEMBL2826295 | 0.83 | HRH3 (0.50) | KDM4EMAPTHRH3ALDH1A1DGAT1 | |
| SCHEMBL2830938 | 0.83 | HRH3 (0.50) | KDM4EMAPTHRH3ALDH1A1DGAT1 | |
| Cyclopentane SCHEMBL2825703 | 0.83 | HRH3 (0.50) | KDM4EMAPTHRH3ALDH1A1DGAT1 | |
| Cyclohexane SCHEMBL2824747 | 0.83 | HRH3 (0.50) | KDM4EMAPTHRH3ALDH1A1DGAT1 | |
| SCHEMBL2828759 | 0.78 | MAPT (0.55) | KDM4EPKMMAPTHRH3CA12 | |
| SCHEMBL2827804 | 0.77 | MEN1 (0.52) | KDM4EMAPTSMN1; SMN2HRH3CA12 | |
| SCHEMBL2825546 | 0.77 | WNT3A (0.52) | KDM4EMAPTSMN1; SMN2HRH3ALDH1A1 | |
| SCHEMBL2825785 | 0.77 | KDM4E (0.48) | KDM4EMAPTHRH3ALDH1A1DGAT1 | |
| SCHEMBL2826412 | 0.76 | MAPT (0.52) | KDM4EMAPTSMN1; SMN2HRH3ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1824829-B1 | 3-SUBSTITUTED PYRIDINE DERIVATIVES AS H3 ANTAGONISTS | HOFFMANN LA ROCHE (CH) | 2010-05-05 | — | — | EP | disclosed |
| EP-1824829-A1 | 3-SUBSTITUTED PYRIDINE DERIVATIVES AS H3 ANTAGONISTS | F. Hoffmann-Roche AG (CH) | 2007-08-29 | — | — | EP | disclosed |
| WO-2006058649-A1 | 3-SUBSTITUTED PYRIDINE DERIVATIVES AS H3 ANTAGONISTS | F. HOFFMANN-LA ROCHE AG (CH) | 2006-06-08 | — | — | WO | disclosed |