Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | POLB | P06746 | 1/20 | 0.49 |
| ▸ | PRMT1 | Q99873 | 1/20 | 0.48 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.43 |
| ▸ | RORC | P51449 | 1/20 | 0.42 |
| ▸ | CDK1 | P06493 | 1/20 | 0.40 |
| ▸ | MAPKAPK2 | P49137 | 2/20 | 0.40 |
| ▸ | MEN1 | O00255 | 1/20 | 0.40 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.40 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.40 |
| ▸ | PTK2B | Q14289 | 1/20 | 0.40 |
| ▸ | JAK2 | O60674 | 1/20 | 0.39 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.39 |
| ▸ | MMP1 | P03956 | 1/20 | 0.38 |
| ▸ | MMP2 | P08253 | 1/20 | 0.38 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL20721699 | 0.94 | PRMT1 (0.53) | MAPTMAPK1POLBPRMT1TDP1 | |
| SCHEMBL30419454 | 0.94 | PRMT1 (0.53) | MAPTMAPK1POLBPRMT1TDP1 | |
| SCHEMBL2173703 | 0.83 | IGF1R (0.47) | MAPTMAPK1POLBPRMT1TDP1 | |
| SCHEMBL857380 | 0.82 | AAK1 (0.42) | MAPTMAPK1POLBPRMT1TDP1 | |
| SCHEMBL28260460 | 0.79 | MAPT (0.53) | MAPTMAPK1POLBPRMT1TDP1 | |
| SCHEMBL20603986 | 0.78 | TDP1 (0.57) | MAPTMAPK1POLBTDP1MEN1 | |
| SCHEMBL16692462 | 0.78 | PIN1 (0.60) | MAPTMAPK1POLBPRMT1CDK1 | |
| SCHEMBL20627482 | 0.77 | PRMT1 (0.47) | PRMT1RORCCDK1MAPKAPK2EGFR | |
| SCHEMBL30418822 | 0.77 | PRMT1 (0.47) | PRMT1RORCCDK1MAPKAPK2EGFR | |
| SCHEMBL31454988 | 0.77 | MAPK1 (0.43) | MAPTMAPK1POLBTDP1L3MBTL1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109071523-B | Urea compound, preparation method and medical application thereof | 恩瑞生物医药科技（上海）有限公司 | 2022-05-31 | — | — | CN | disclosed |
| CN-109071523-A | Urea compound, preparation method and medical application thereof | 恩瑞生物医药科技（上海）有限公司 | 2018-12-21 | — | — | CN | disclosed |