SCHEMBL28260758

SCHEMBL28260758

BrC1(Br)C=Cc2ccccc2C1

nearest known ligand 0.36

Predicted protein targets (top 8)

geneUniProtsupporting neighboursconfidence
PARP1 P09874 1/20 0.36
CA1 P00915 2/20 0.36
CA2 P00918 2/20 0.36
MAOB P27338 1/20 0.31
GAA P10253 1/20 0.30
MAPT P10636 1/20 0.30
HTR2C P28335 1/20 0.30
HTR2B P41595 1/20 0.30

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL15940564 0.79 PARP1 (0.34) PARP1CA1CA2
SCHEMBL2151230 0.79 PARP1 (0.34) PARP1CA1CA2
SCHEMBL9861975 0.79 PARP1 (0.34) PARP1CA1CA2
SCHEMBL5133900 0.79 PARP1 (0.34) PARP1CA1CA2MAOB
SCHEMBL2288761 0.77 PARP1 (0.39) PARP1CA1CA2MAOBGAA
SCHEMBL29223962 0.76 CA1 (0.33) PARP1CA1CA2
SCHEMBL30274390 0.76 CA1 (0.33) PARP1CA1CA2
SCHEMBL5290390 0.75 PARP1 (0.34) PARP1CA1CA2
SCHEMBL27938830 0.75 CA1 (0.32) PARP1CA1CA2MAOB
SCHEMBL258234 0.74 PARP1 (0.36) PARP1CA1CA2MAOBGAA

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-108912152-A β -dicarbonyl boron fluoride compound and preparation method and application thereof 中国科学院理化技术研究所 2018-11-30 CN disclosed