Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PI4KA | P42356 | 1/20 | 0.47 |
| ▸ | PI4K2B | Q8TCG2 | 1/20 | 0.47 |
| ▸ | PI4K2A | Q9BTU6 | 1/20 | 0.47 |
| ▸ | PI4KB | Q9UBF8 | 1/20 | 0.47 |
| ▸ | PDE4A | P27815 | 1/20 | 0.47 |
| ▸ | PDE4B | Q07343 | 1/20 | 0.47 |
| ▸ | PDE4C | Q08493 | 1/20 | 0.47 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.47 |
| ▸ | GALR3 | O60755 | 1/20 | 0.46 |
| ▸ | NR2F2 | P24468 | 1/20 | 0.46 |
| ▸ | ADORA2A | P29274 | 2/20 | 0.44 |
| ▸ | EGFR | P00533 | 2/20 | 0.42 |
| ▸ | BCAT2 | O15382 | 1/20 | 0.42 |
| ▸ | DAPK3 | O43293 | 1/20 | 0.41 |
| ▸ | MAP4K4 | O95819 | 1/20 | 0.41 |
| ▸ | ABL1 | P00519 | 1/20 | 0.41 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.41 |
| ▸ | PIM1 | P11309 | 1/20 | 0.41 |
| ▸ | PRKACA | P17612 | 1/20 | 0.41 |
| ▸ | LTK | P29376 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6371765 | 0.86 | PI4KA (0.52) | PI4KAPI4K2BPI4K2API4KBPDE4A | |
| SCHEMBL20115779 | 0.78 | PI4KA (0.44) | PI4KAPI4K2BPI4K2API4KBPDE4A | |
| SCHEMBL21362866 | 0.75 | SMN1; SMN2 (0.43) | PI4KAPI4K2BPI4K2API4KBPDE4A | |
| SCHEMBL30838566 | 0.71 | LMNA (0.44) | PI4KAPI4K2BPI4K2API4KBPDE4A | |
| SCHEMBL7486261 | 0.70 | PI4KA (0.48) | PI4KAPI4K2BPI4K2API4KBPDE4A | |
| SCHEMBL10562950 | 0.70 | MAPT (0.48) | NPC1RAB9AMAPTKMT2ASMN1; SMN2 | |
| SCHEMBL3951708 | 0.69 | PI4KA (0.56) | PI4KAPI4K2BPI4K2API4KBPDE4A | |
| SCHEMBL637552 | 0.69 | PI4KA (0.56) | PI4KAPI4K2BPI4K2API4KBPDE4A | |
| SCHEMBL22918311 | 0.68 | SMN1; SMN2 (0.54) | PI4KAPI4K2BPI4K2API4KBPDE4A | |
| SCHEMBL803121 | 0.68 | PI4KA (0.50) | PI4KAPI4K2BPI4K2API4KBPDE4A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-108884061-A | 1,2,4- triazine -3- amine derivant, preparation method and its application in medicine | 江苏恒瑞医药股份有限公司 | 2018-11-23 | — | — | CN | disclosed |