Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PLK4 | O00444 | 3/20 | 0.50 |
| ▸ | PLK1 | P53350 | 3/20 | 0.50 |
| ▸ | RET | P07949 | 1/20 | 0.50 |
| ▸ | FLT3 | P36888 | 1/20 | 0.50 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.50 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.50 |
| ▸ | IDO1 | P14902 | 2/20 | 0.44 |
| ▸ | TDO2 | P48775 | 1/20 | 0.44 |
| ▸ | MAOA | P21397 | 1/20 | 0.44 |
| ▸ | MAOB | P27338 | 1/20 | 0.44 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.44 |
| ▸ | FER | P16591 | 1/20 | 0.44 |
| ▸ | LTK | P29376 | 1/20 | 0.44 |
| ▸ | CDK8 | P49336 | 1/20 | 0.44 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.44 |
| ▸ | LRRK2 | Q5S007 | 1/20 | 0.44 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | MAP3K7 | O43318 | 2/20 | 0.41 |
| ▸ | TAB1 | Q15750 | 2/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13207305 | 1.00 | PLK4 (0.50) | PLK4PLK1RETFLT3PDGFRB | |
| SCHEMBL2826123 | 1.00 | PLK4 (0.50) | PLK4PLK1RETFLT3PDGFRB | |
| SCHEMBL2829329 | 0.89 | TDP1 (0.50) | TDP1IDO1TDO2MAOAMAOB | |
| SCHEMBL2829327 | 0.89 | TDP1 (0.50) | TDP1IDO1TDO2MAOAMAOB | |
| SCHEMBL13207359 | 0.86 | TDP1 (0.49) | TDP1IDO1TDO2MAOAMAOB | |
| SCHEMBL2829139 | 0.86 | TDP1 (0.49) | TDP1IDO1TDO2MAOAMAOB | |
| SCHEMBL2829194 | 0.86 | TDP1 (0.49) | TDP1IDO1TDO2MAOAMAOB | |
| SCHEMBL13207307 | 0.86 | TDP1 (0.49) | TDP1IDO1TDO2MAOAMAOB | |
| SCHEMBL2829197 | 0.86 | TDP1 (0.49) | TDP1IDO1TDO2MAOAMAOB | |
| SCHEMBL4999345 | 0.86 | TDP1 (0.52) | TDP1IDO1TDO2MAOAMAOB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 7 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7781475-B2 | Oxindoles as kinase inhibitors | MERCK PATENT GMBH (DE) | 2010-08-24 | — | — | US | claimed |
| US-20100197757-A1 | OXINDOLES AS KINASE INHIBITORS | BURGDORF LARS THORE | 2010-08-05 | — | — | US | claimed |
| US-20090131506-A1 | Oxindoles as Kinase Inhibitors | MERCK PATENT GMBH (DE) | 2009-05-21 | — | — | US | claimed |
| US-7781475-B2 | Oxindoles as kinase inhibitors | MERCK PATENT GMBH (DE) | 2010-08-24 | — | — | US | disclosed |
| US-20100197757-A1 | OXINDOLES AS KINASE INHIBITORS | BURGDORF LARS THORE | 2010-08-05 | — | — | US | disclosed |
| EP-1891008-B1 | OXINDOLES AS KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2010-06-30 | — | — | EP | disclosed |
| US-20090131506-A1 | Oxindoles as Kinase Inhibitors | MERCK PATENT GMBH (DE) | 2009-05-21 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (2 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20100197757-A1 | OXINDOLES AS KINASE INHIBITORS | MAP4K2, MAP3K20, MAP3K1 | PLK4 371/4885PLK1 212/4885RET 362/4885 |
| US-20090131506-A1 | Oxindoles as Kinase Inhibitors | MAP4K2, MAP3K20, MAP3K1 | PLK4 371/4885PLK1 212/4885RET 362/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.