Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 2/20 | 0.50 |
| ▸ | LRRK2 | Q5S007 | 3/20 | 0.48 |
| ▸ | MAOA | P21397 | 1/20 | 0.48 |
| ▸ | MAOB | P27338 | 1/20 | 0.48 |
| ▸ | PDGFRA | P16234 | 1/20 | 0.48 |
| ▸ | FER | P16591 | 1/20 | 0.48 |
| ▸ | LTK | P29376 | 1/20 | 0.48 |
| ▸ | CDK8 | P49336 | 1/20 | 0.48 |
| ▸ | ACVR1 | Q04771 | 1/20 | 0.48 |
| ▸ | DYRK1B | Q9Y463 | 1/20 | 0.48 |
| ▸ | IDO1 | P14902 | 4/20 | 0.48 |
| ▸ | TDO2 | P48775 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.47 |
| ▸ | MAPT | P10636 | 4/20 | 0.47 |
| ▸ | NPSR1 | Q6W5P4 | 3/20 | 0.47 |
| ▸ | LMNA | P02545 | 2/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.47 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.47 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.44 |
| ▸ | PKM | P14618 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2829329 | 1.00 | TDP1 (0.50) | TDP1LRRK2MAOAMAOBPDGFRA | |
| SCHEMBL13207305 | 0.89 | PLK4 (0.50) | TDP1LRRK2MAOAMAOBPDGFRA | |
| SCHEMBL2826121 | 0.89 | PLK4 (0.50) | TDP1LRRK2MAOAMAOBPDGFRA | |
| SCHEMBL2826123 | 0.89 | PLK4 (0.50) | TDP1LRRK2MAOAMAOBPDGFRA | |
| SCHEMBL13207307 | 0.87 | TDP1 (0.49) | TDP1LRRK2MAOAMAOBPDGFRA | |
| SCHEMBL2829139 | 0.87 | TDP1 (0.49) | TDP1LRRK2MAOAMAOBPDGFRA | |
| SCHEMBL2829194 | 0.87 | TDP1 (0.49) | TDP1LRRK2MAOAMAOBPDGFRA | |
| SCHEMBL4999345 | 0.87 | TDP1 (0.52) | TDP1LRRK2MAOAMAOBPDGFRA | |
| SCHEMBL13207359 | 0.87 | TDP1 (0.49) | TDP1LRRK2MAOAMAOBPDGFRA | |
| SCHEMBL2829197 | 0.87 | TDP1 (0.49) | TDP1LRRK2MAOAMAOBPDGFRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1891008-B1 | OXINDOLES AS KINASE INHIBITORS | MERCK PATENT GMBH (DE) | 2010-06-30 | — | — | EP | disclosed |