Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 1.00 |
| ▸ | FGFR1 | P11362 | 4/20 | 1.00 |
| ▸ | ABL1 | P00519 | 1/20 | 0.62 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.62 |
| ▸ | KIT | P10721 | 1/20 | 0.62 |
| ▸ | SRC | P12931 | 1/20 | 0.62 |
| ▸ | BRAF | P15056 | 1/20 | 0.62 |
| ▸ | KDR | P35968 | 1/20 | 0.62 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.62 |
| ▸ | TEK | Q02763 | 1/20 | 0.62 |
| ▸ | ERBB3 | P21860 | 6/20 | 0.55 |
| ▸ | TUBB4A | P04350 | 1/20 | 0.54 |
| ▸ | TUBB | P07437 | 1/20 | 0.54 |
| ▸ | TUBA3C | P0DPH7 | 1/20 | 0.54 |
| ▸ | TUBA1B | P68363 | 1/20 | 0.54 |
| ▸ | TUBA4A | P68366 | 1/20 | 0.54 |
| ▸ | TUBB4B | P68371 | 1/20 | 0.54 |
| ▸ | TUBB3 | Q13509 | 1/20 | 0.54 |
| ▸ | TUBB2A | Q13885 | 1/20 | 0.54 |
| ▸ | TUBB8 | Q3ZCM7 | 1/20 | 0.54 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL374173 | 0.86 | EGFR (0.75) | EGFRFGFR1ABL1PDGFRBKIT | |
| SCHEMBL374439 | 0.84 | EGFR (0.72) | EGFRFGFR1ERBB3TUBB4ATUBB | |
| SCHEMBL28260312 | 0.84 | EGFR (1.00) | EGFRFGFR1ABL1PDGFRBKIT | |
| SCHEMBL374328 | 0.82 | EGFR (0.74) | EGFRFGFR1ABL1PDGFRBKIT | |
| SCHEMBL379004 | 0.82 | EGFR (0.69) | EGFRFGFR1ABL1PDGFRBKIT | |
| SCHEMBL28515327 | 0.80 | EGFR (1.00) | EGFRFGFR1ABL1PDGFRBKIT | |
| SCHEMBL28503748 | 0.80 | EGFR (0.66) | EGFRFGFR1ABL1PDGFRBKIT | |
| SCHEMBL374014 | 0.80 | EGFR (0.66) | EGFRFGFR1ABL1PDGFRBKIT | |
| SCHEMBL373717 | 0.80 | EGFR (0.80) | EGFRFGFR1ERBB3TUBB4ATUBB | |
| SCHEMBL374617 | 0.78 | EGFR (0.63) | EGFRFGFR1ABL1PDGFRBKIT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109053593-A | 1- (2,6- chlorphenyl) -3- (substituted pyrimidines -4- base) carbamide compounds and its preparation and application | 温州医科大学 | 2018-12-21 | — | — | CN | claimed |
| CN-109053593-B | 1- (2, 6-chlorphenyl) -3- (substituted pyrimidine-4-yl) urea compound and preparation and application thereof | 温州医科大学 | 2020-12-04 | — | — | CN | disclosed |