Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 1.00 |
| ▸ | FGFR1 | P11362 | 4/20 | 1.00 |
| ▸ | ERBB3 | P21860 | 4/20 | 0.61 |
| ▸ | KDR | P35968 | 2/20 | 0.56 |
| ▸ | ABL1 | P00519 | 1/20 | 0.56 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.56 |
| ▸ | KIT | P10721 | 1/20 | 0.56 |
| ▸ | SRC | P12931 | 1/20 | 0.56 |
| ▸ | BRAF | P15056 | 1/20 | 0.56 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.56 |
| ▸ | TEK | Q02763 | 1/20 | 0.56 |
| ▸ | FGFR3 | P22607 | 3/20 | 0.52 |
| ▸ | MEN1 | O00255 | 4/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 4/20 | 0.48 |
| ▸ | MAPT | P10636 | 3/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.47 |
| ▸ | LCK | P06239 | 1/20 | 0.47 |
| ▸ | GAA | P10253 | 2/20 | 0.47 |
| ▸ | USP2 | O75604 | 1/20 | 0.47 |
| ▸ | LMNA | P02545 | 1/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28905573 | 0.86 | EGFR (0.75) | EGFRFGFR1ERBB3KDRABL1 | |
| SCHEMBL28261624 | 0.84 | EGFR (1.00) | EGFRFGFR1ERBB3KDRABL1 | |
| SCHEMBL28515074 | 0.83 | EGFR (0.71) | EGFRFGFR1ERBB3KDRABL1 | |
| SCHEMBL374876 | 0.83 | EGFR (0.71) | EGFRFGFR1ERBB3FGFR3MEN1 | |
| SCHEMBL28498357 | 0.79 | EGFR (0.66) | EGFRFGFR1ERBB3FGFR3MEN1 | |
| SCHEMBL28514560 | 0.77 | EGFR (0.64) | EGFRFGFR1KDRABL1PDGFRB | |
| SCHEMBL374173 | 0.77 | EGFR (0.75) | EGFRFGFR1ERBB3KDRABL1 | |
| SCHEMBL28489979 | 0.76 | EGFR (0.62) | EGFRFGFR1ERBB3MEN1KMT2A | |
| SCHEMBL28465755 | 0.75 | EGFR (0.65) | EGFRFGFR1ERBB3SRCMEN1 | |
| SCHEMBL28497440 | 0.75 | EGFR (0.60) | EGFRFGFR1ERBB3FGFR3MEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109053593-B | 1- (2, 6-chlorphenyl) -3- (substituted pyrimidine-4-yl) urea compound and preparation and application thereof | 温州医科大学 | 2020-12-04 | — | — | CN | claimed |
| CN-109053593-A | 1- (2,6- chlorphenyl) -3- (substituted pyrimidines -4- base) carbamide compounds and its preparation and application | 温州医科大学 | 2018-12-21 | — | — | CN | claimed |
| CN-109053593-B | 1- (2, 6-chlorphenyl) -3- (substituted pyrimidine-4-yl) urea compound and preparation and application thereof | 温州医科大学 | 2020-12-04 | — | — | CN | disclosed |