SCHEMBL2826224

SCHEMBL2826224

NCCCC(=O)NCC#CCNc1ncnc2nc[nH]c12

nearest known ligand 0.56

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 1/20 0.56
HDAC2 Q92769 1/20 0.56
TSHR P16473 4/20 0.49
HSD17B10 Q99714 2/20 0.49
TP53 P04637 1/20 0.49
HTT P42858 2/20 0.48
CYP3A4 P08684 1/20 0.48
CYP1A2 P05177 3/20 0.47
CDK2 P24941 2/20 0.47
LMNA P02545 3/20 0.45
RECQL P46063 1/20 0.45
SMN1; SMN2 Q16637 1/20 0.45
AURKA O14965 1/20 0.44
HIF1A Q16665 1/20 0.44
PRMT1 Q99873 1/20 0.44
CYP2D6 P10635 1/20 0.43
MAPK1 P28482 1/20 0.43
BRD4 O60885 2/20 0.42
MKNK1 Q9BUB5 1/20 0.42
BRAF P15056 1/20 0.42

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2826232 0.84 HDAC1 (0.37) HDAC1HDAC2TSHRHSD17B10TP53
SCHEMBL1895229 0.72 HDAC1 (0.64) HDAC1HDAC2TSHRHSD17B10TP53
SCHEMBL29407252 0.72 HDAC1 (0.64) HDAC1HDAC2TSHRHSD17B10TP53
SCHEMBL1542462 0.72 HDAC1 (0.64) HDAC1HDAC2TSHRHSD17B10TP53
SCHEMBL10345057 0.72 HDAC1 (0.67) HDAC1HDAC2TSHRHSD17B10TP53
SCHEMBL10836915 0.72 HTT (0.71) HDAC1HDAC2TSHRHSD17B10TP53
SCHEMBL38663949 0.71 BRD4 (0.58) HDAC1HDAC2TSHRHSD17B10TP53
SCHEMBL18259659 0.71 TSHR (0.65) HDAC1HDAC2TSHRHSD17B10TP53
SCHEMBL31373431 0.70 HTT (0.65) TSHRHSD17B10TP53HTTCYP3A4
SCHEMBL7052324 0.70 HDAC1 (0.61) HDAC1HDAC2TSHRHSD17B10TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1874790-B1 NEW S-ADENOSYL-L-METHIONINE ANALOGS WITH EXTENDED ACTIVATED GROUPS FOR TRANSFER BY METHYLTRANSFERASES RWTH AACHEN (DE) 2010-08-18 EP disclosed
EP-1874790-A2 NEW S-ADENOSYL-L-METHIONINE ANALOGS WITH EXTENDED ACTIVATED GROUPS FOR TRANSFER BY METHYLTRANSFERASES RWTH Aachen (DE) 2008-01-09 EP disclosed
WO-2006108678-A2 NEW S-ADENOSYL-L-METHIONINE ANALOGS WITH EXTENDED ACTIVATED GROUPS FOR TRANSFER BY METHYLTRANSFERASES RWTH AACHEN (DE) 2006-10-19 WO disclosed