SCHEMBL2826232

SCHEMBL2826232

NCCCC(=O)NCC#CCNc1ncnc2[nH]cnc12

nearest known ligand 0.37

Predicted protein targets (top 13)

geneUniProtsupporting neighboursconfidence
HDAC1 Q13547 3/20 0.37
HDAC2 Q92769 3/20 0.37
XDH P47989 1/20 0.34
TSHR P16473 2/20 0.32
CYP3A4 P08684 2/20 0.32
CYP2D6 P10635 1/20 0.32
CYP2C19 P33261 1/20 0.32
TP53 P04637 1/20 0.31
HSD17B10 Q99714 1/20 0.31
CA1 P00915 2/20 0.31
CA2 P00918 2/20 0.31
LMNA P02545 1/20 0.31
AURKA O14965 1/20 0.31

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL2826224 0.84 HDAC1 (0.56) HDAC1HDAC2TSHRCYP3A4CYP2D6
SCHEMBL1369446 0.81 XDH (0.45) HDAC1HDAC2XDHCA1CA2
Hydrochloric Acid SCHEMBL1370010 0.80 XDH (0.44) HDAC1HDAC2XDHCA1CA2
SCHEMBL9835402 0.78 CYP3A4 (0.37) HDAC1HDAC2TSHRCYP3A4TP53
SCHEMBL19064641 0.75 HTT (0.36) TSHRCYP3A4CYP2D6TP53HSD17B10
SCHEMBL23019062 0.73 CYP1A2 (0.44) TSHRCYP3A4CYP2D6CYP2C19HSD17B10
SCHEMBL1369225 0.72 XDH (0.41) HDAC1HDAC2XDHTSHRCYP3A4
Hydrochloric Acid SCHEMBL1371823 0.71 XDH (0.40) HDAC1HDAC2XDHTSHRCYP3A4
SCHEMBL2623138 0.71 XDH (0.62) HDAC1HDAC2XDHCA1CA2
SCHEMBL1895231 0.71 HDAC1 (0.41) HDAC1HDAC2TSHRCYP3A4TP53

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-1874790-B1 NEW S-ADENOSYL-L-METHIONINE ANALOGS WITH EXTENDED ACTIVATED GROUPS FOR TRANSFER BY METHYLTRANSFERASES RWTH AACHEN (DE) 2010-08-18 EP disclosed
EP-1874790-A2 NEW S-ADENOSYL-L-METHIONINE ANALOGS WITH EXTENDED ACTIVATED GROUPS FOR TRANSFER BY METHYLTRANSFERASES RWTH Aachen (DE) 2008-01-09 EP disclosed
WO-2006108678-A2 NEW S-ADENOSYL-L-METHIONINE ANALOGS WITH EXTENDED ACTIVATED GROUPS FOR TRANSFER BY METHYLTRANSFERASES RWTH AACHEN (DE) 2006-10-19 WO disclosed