Predicted protein targets (top 11)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MKNK1 | Q9BUB5 | 1/20 | 0.43 |
| ▸ | CHRM5 | P08912 | 5/20 | 0.41 |
| ▸ | CHRM3 | P20309 | 5/20 | 0.41 |
| ▸ | CHRM2 | P08172 | 5/20 | 0.41 |
| ▸ | CHRM1 | P11229 | 4/20 | 0.41 |
| ▸ | CHRM4 | P08173 | 4/20 | 0.41 |
| ▸ | CHRNB2 | P17787 | 2/20 | 0.41 |
| ▸ | CHRNA4 | P43681 | 2/20 | 0.41 |
| ▸ | CHRNA7 | P36544 | 1/20 | 0.41 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.40 |
| ▸ | CDK9 | P50750 | 1/20 | 0.40 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28263444 | 1.00 | MKNK1 (0.43) | MKNK1CHRM5CHRM3CHRM2CHRM1 | |
| SCHEMBL18729675 | 0.81 | CHRNB4 (0.47) | MKNK1CHRM5CHRM3CHRM2CHRM1 | |
| SCHEMBL18729676 | 0.81 | CHRNB4 (0.47) | MKNK1CHRM5CHRM3CHRM2CHRM1 | |
| SCHEMBL20575902 | 0.74 | CHRM5 (0.46) | CHRM5CHRM3CHRM2CHRM1CHRM4 | |
| SCHEMBL29589051 | 0.74 | CHRM5 (0.46) | CHRM5CHRM3CHRM2CHRM1CHRM4 | |
| Hydrochloric Acid SCHEMBL31444377 | 0.73 | CHRM5 (0.44) | CHRM5CHRM3CHRM2CHRM1CHRM4 | |
| SCHEMBL11288607 | 0.71 | CHRNB2 (0.52) | MKNK1CHRM5CHRM3CHRM2CHRM1 | |
| Hydrochloric Acid SCHEMBL28094487 | 0.70 | CHRNB2 (0.51) | MKNK1CHRM5CHRM3CHRM2CHRM1 | |
| SCHEMBL1765240 | 0.69 | MEN1 (0.46) | CHRM5CHRM3CHRM2CHRM1CHRM4 | |
| SCHEMBL3170242 | 0.69 | CHRM2 (0.44) | MKNK1CHRM5CHRM3CHRM2CHRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110003214-A | Substituted pyrazolo [1,5-a] pyrimidine compound as TRK kinase inhibitor | 阵列生物制药公司 | 2019-07-12 | — | — | CN | disclosed |
| CN-106008523-B | Substituted pyrazolo [1,5-a] pyrimidine compound as TRK kinase inhibitor | 阵列生物制药公司 | 2019-01-25 | — | — | CN | disclosed |