Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | THRB | P10828 | 14/20 | 0.44 |
| ▸ | THRA | P10827 | 13/20 | 0.44 |
| ▸ | PTGS1 | P23219 | 1/20 | 0.32 |
| ▸ | PTGS2 | P35354 | 1/20 | 0.32 |
| ▸ | RXRA | P19793 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL283129 | 0.75 | THRB (0.76) | THRBTHRA | |
| SCHEMBL328293 | 0.74 | THRB (0.52) | THRBTHRAPTGS1PTGS2 | |
| SCHEMBL13381667 | 0.74 | THRB (0.49) | THRBTHRA | |
| SCHEMBL3748866 | 0.74 | THRB (0.49) | THRBTHRA | |
| SCHEMBL13381666 | 0.73 | THRB (0.65) | THRBTHRA | |
| SCHEMBL27733469 | 0.73 | THRB (0.35) | THRBTHRA | |
| SCHEMBL282541 | 0.72 | THRB (0.77) | THRBTHRA | |
| SCHEMBL282437 | 0.72 | THRB (0.50) | THRBTHRA | |
| SCHEMBL13381655 | 0.71 | THRB (0.65) | THRBTHRA | |
| SCHEMBL282457 | 0.70 | THRB (0.43) | THRBTHRA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2428516-A1 | Novel phosphorus-containing thyromimetics | Metabasis Therapeutics, Inc. (US) | 2012-03-14 | — | — | EP | disclosed |