SCHEMBL28264689

SCHEMBL28264689

CC(C)[Si](Oc1ccc(C(=O)c2ccc(O[Si](C(C)C)(C(C)C)C(C)C)cc2[N+](=O)[O-])c([N+](=O)[O-])c1)(C(C)C)C(C)C

nearest known ligand 0.39

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
ALDH1A1 P00352 5/20 0.39
MAPK1 P28482 4/20 0.39
MEN1 O00255 1/20 0.39
KMT2A Q03164 1/20 0.39
LMNA P02545 4/20 0.39
MAPT P10636 4/20 0.37
RAF1 P04049 1/20 0.37
HPGD P15428 1/20 0.37
GFER P55789 1/20 0.37
PAX8 Q06710 1/20 0.37
KDM4E B2RXH2 2/20 0.37
HTT P42858 2/20 0.37
AKR1C3 P42330 1/20 0.36
AKR1C2 P52895 1/20 0.36
NPC1 O15118 2/20 0.36
RAB9A P51151 2/20 0.36
CYP1A2 P05177 1/20 0.36
CYP3A4 P08684 1/20 0.36
CYP2D6 P10635 1/20 0.36
CYP2C19 P33261 1/20 0.36

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL1663030 0.81 ALDH1A1 (0.47) ALDH1A1MAPK1MEN1KMT2AMAPT
SCHEMBL1663051 0.80 POLB (0.49) ALDH1A1LMNAMAPTHPGDNPC1
SCHEMBL9108332 0.79 ALDH1A1 (0.43) ALDH1A1MAPK1MEN1KMT2ALMNA
SCHEMBL28264690 0.77 ALDH1A1 (0.44) ALDH1A1MAPK1KMT2AMAPTHPGD
SCHEMBL2770853 0.77 ATM (0.49) ALDH1A1MEN1KMT2ALMNAMAPT
SCHEMBL9107612 0.72 ALDH1A1 (0.63) ALDH1A1MEN1KMT2AMAPTKDM4E
SCHEMBL9112833 0.72 GAA (0.49) ALDH1A1MAPK1MEN1KMT2ALMNA
Methyl Alcohol SCHEMBL28009562 0.71 ALDH1A1 (0.49) ALDH1A1MAPK1MEN1KMT2ALMNA
SCHEMBL22065392 0.71 ALDH1A1 (0.52) ALDH1A1MAPK1MEN1KMT2ALMNA
SCHEMBL17403321 0.70 TSHR (0.47) MEN1KMT2ALMNAMAPTHPGD

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
CN-109134599-A Pyrrolobenzodiazepines Zhuo and its conjugate 麦迪穆有限责任公司 2019-01-04 CN disclosed