Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.38 |
| ▸ | CCNC | P24863 | 7/20 | 0.37 |
| ▸ | CDK8 | P49336 | 7/20 | 0.37 |
| ▸ | CDK19 | Q9BWU1 | 2/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.36 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.35 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.35 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.35 |
| ▸ | CDK9 | P50750 | 1/20 | 0.35 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.35 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.34 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.33 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.33 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.33 |
| ▸ | DAO | P14920 | 1/20 | 0.33 |
| ▸ | MEN1 | O00255 | 1/20 | 0.33 |
| ▸ | POLB | P06746 | 1/20 | 0.33 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.33 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Tert-Butyl Formate SCHEMBL27572989 | 0.88 | TDP1 (0.39) | TDP1MAPTCCNCCDK8CDK19 | |
| Ethoxycarbonyl Group SCHEMBL27647387 | 0.81 | CCNC (0.43) | MAPTCCNCCDK8CDK19CYP2A6 | |
| Formic Acid SCHEMBL30557216 | 0.80 | CCNC (0.44) | MAPTCCNCCDK8CDK19CYP2A6 | |
| Formic Acid SCHEMBL23291890 | 0.80 | CCNC (0.44) | MAPTCCNCCDK8CDK19CYP2A6 | |
| SCHEMBL12470 | 0.80 | — | — | |
| SCHEMBL29465576 | 0.80 | — | — | |
| SCHEMBL706764 | 0.80 | MAPT (0.50) | MAPTCCNCCDK8TLR8TLR7 | |
| SCHEMBL7491548 | 0.78 | MAPT (0.49) | MAPTCCNCCDK8TLR8TLR7 | |
| Hydrochloric Acid SCHEMBL5532283 | 0.78 | MAPT (0.49) | MAPTCCNCCDK8TLR8TLR7 | |
| Hydrochloric Acid SCHEMBL2978417 | 0.78 | MAPT (0.49) | MAPTCCNCCDK8TLR8TLR7 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-110382494-A | Substituted pyrazolo [1,5-A ] pyridine compounds as RET kinase inhibitors | 阿雷生物药品公司 | 2019-10-25 | — | — | CN | disclosed |
| CN-105960404-B | The inhibitor of bruton's tyrosine kinase | 药品循环有限责任公司 | 2019-09-03 | — | — | CN | disclosed |
| CN-106661018-B | Pyrrolo- [2,3-C] pyridine as neurofibrillary tangles imaging agent | 默沙东公司 | 2019-07-19 | — | — | CN | disclosed |
| CN-105829310-B | bicyclic heterocyclic compounds and their therapeutic use | 阿斯特克斯治疗有限公司 | 2019-04-12 | — | — | CN | disclosed |
| CN-109153646-A | Pyridine dicarboxamide derivatives as bromine structural domain inhibitor | 葛兰素史克知识产权第二有限公司 | 2019-01-04 | — | — | CN | disclosed |
| CN-109069869-A | Bicyclic PAD4 inhibitor | 帕德罗科治疗公司 | 2018-12-21 | — | — | CN | disclosed |