Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CCNC | P24863 | 6/20 | 0.43 |
| ▸ | CDK8 | P49336 | 6/20 | 0.43 |
| ▸ | CDK19 | Q9BWU1 | 2/20 | 0.43 |
| ▸ | MAPT | P10636 | 1/20 | 0.37 |
| ▸ | CYP2A6 | P11509 | 2/20 | 0.35 |
| ▸ | TLR8 | Q9NR97 | 1/20 | 0.34 |
| ▸ | TLR7 | Q9NYK1 | 1/20 | 0.34 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.34 |
| ▸ | CDK9 | P50750 | 1/20 | 0.34 |
| ▸ | HASPIN | Q8TF76 | 1/20 | 0.34 |
| ▸ | KDM4C | Q9H3R0 | 1/20 | 0.33 |
| ▸ | HRH4 | Q9H3N8 | 1/20 | 0.33 |
| ▸ | KDM5A | P29375 | 1/20 | 0.33 |
| ▸ | KDM5B | Q9UGL1 | 1/20 | 0.33 |
| ▸ | MAOA | P21397 | 1/20 | 0.33 |
| ▸ | PIK3CD | O00329 | 1/20 | 0.32 |
| ▸ | PIK3CB | P42338 | 1/20 | 0.32 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.32 |
| ▸ | CYP17A1 | P05093 | 1/20 | 0.32 |
| ▸ | CYP11B1 | P15538 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethoxycarbonyl Group SCHEMBL27637863 | 0.88 | CCNC (0.43) | CCNCCDK8CDK19MAPTCYP2A6 | |
| Tert-Butyl Formate SCHEMBL28265077 | 0.81 | TDP1 (0.39) | CCNCCDK8CDK19MAPTCYP2A6 | |
| Formic Acid SCHEMBL23291890 | 0.79 | CCNC (0.44) | CCNCCDK8CDK19MAPTCYP2A6 | |
| Formic Acid SCHEMBL30557216 | 0.79 | CCNC (0.44) | CCNCCDK8CDK19MAPTCYP2A6 | |
| SCHEMBL706764 | 0.79 | MAPT (0.50) | CCNCCDK8MAPTTLR8TLR7 | |
| SCHEMBL29465576 | 0.79 | — | — | |
| SCHEMBL12470 | 0.79 | — | — | |
| Indole SCHEMBL27375410 | 0.78 | TRPA1 (0.57) | CYP2A6MAOAMEN1POLBMAPK1 | |
| Propylformate SCHEMBL28127351 | 0.77 | CCNC (0.39) | CCNCCDK8CDK19MAPTCYP2A6 | |
| Ethoxycarbonyl Group SCHEMBL28014965 | 0.77 | CYP17A1 (0.58) | CCNCCDK8TLR8TLR7CYP17A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-101790313-A | Compound (I) | SMITHKLINE BEECHAM CORP | 2010-07-28 | — | — | CN | disclosed |
| CN-100439367-C | Substituted 1H-pyrrolo[3,2-b, 3,2-c, and 2,3-c]pyridine-2-carboxamides and related analogs as inhibitors of casein kinase lepsilon | AVENTIS PHARMA INC (US) | 2008-12-03 | — | — | CN | disclosed |
| CN-101166739-A | Substituted pyrrolopyridines, compositions containing them, process for their preparation and their use | AVENTIS PHARMA SA (FR) | 2008-04-23 | — | — | CN | disclosed |
| CN-1906194-A | Substituted 1H-pyrrolo [3, 2-b, 3, 2-c and 2, 3-c ] pyridine-2-carboxamides and related analogs as inhibitors of casein kinase ie | AVENTIS PHARMA INC (US) | 2007-01-31 | — | — | CN | disclosed |