Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KMT2A | Q03164 | 3/20 | 0.52 |
| ▸ | GAA | P10253 | 3/20 | 0.52 |
| ▸ | POLB | P06746 | 2/20 | 0.52 |
| ▸ | MEN1 | O00255 | 2/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 7/20 | 0.52 |
| ▸ | KDM4E | B2RXH2 | 7/20 | 0.52 |
| ▸ | HSD17B10 | Q99714 | 6/20 | 0.52 |
| ▸ | HPGD | P15428 | 5/20 | 0.52 |
| ▸ | USP2 | O75604 | 1/20 | 0.51 |
| ▸ | JAK2 | O60674 | 1/20 | 0.51 |
| ▸ | MAPK1 | P28482 | 2/20 | 0.49 |
| ▸ | MAPT | P10636 | 2/20 | 0.49 |
| ▸ | MMP14 | P50281 | 1/20 | 0.49 |
| ▸ | LMNA | P02545 | 2/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.45 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28265768 | 0.84 | SMN1; SMN2 (0.50) | KMT2AGAAMEN1ALDH1A1KDM4E | |
| SCHEMBL6985080 | 0.79 | KMT2A (0.60) | KMT2AGAAPOLBMEN1ALDH1A1 | |
| SCHEMBL4473290 | 0.77 | POLB (0.53) | KMT2AGAAPOLBMEN1ALDH1A1 | |
| SCHEMBL17194217 | 0.74 | KMT2A (0.73) | KMT2AGAAPOLBMEN1ALDH1A1 | |
| SCHEMBL12793245 | 0.73 | POLB (0.88) | KMT2AGAAPOLBMEN1ALDH1A1 | |
| SCHEMBL17290538 | 0.73 | KMT2A (0.52) | KMT2AGAAPOLBMEN1ALDH1A1 | |
| SCHEMBL17295351 | 0.73 | KMT2A (0.52) | KMT2AGAAPOLBMEN1ALDH1A1 | |
| SCHEMBL15756908 | 0.73 | KDM4E (0.52) | KMT2AGAAPOLBMEN1ALDH1A1 | |
| SCHEMBL10306750 | 0.72 | POLB (0.73) | KMT2AGAAPOLBMEN1ALDH1A1 | |
| SCHEMBL78621 | 0.72 | POLB (0.73) | KMT2AGAAPOLBMEN1ALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-105143206-B | Pyrimidine -2,4- diamine derivative for treating cancer | 托马斯·黑勒戴药物研究基金会 | 2019-01-15 | — | — | CN | disclosed |
| CN-106794181-A | MTH1 inhibitors for the treatment of inflammatory and autoimmune conditions | 托马斯·黑勒戴药物研究基金会 | 2017-05-31 | — | — | CN | disclosed |