Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | POLB | P06746 | 2/20 | 0.53 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.53 |
| ▸ | GAA | P10253 | 2/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.53 |
| ▸ | JAK2 | O60674 | 1/20 | 0.52 |
| ▸ | ALDH1A1 | P00352 | 5/20 | 0.49 |
| ▸ | KDM4E | B2RXH2 | 4/20 | 0.49 |
| ▸ | HSD17B10 | Q99714 | 4/20 | 0.49 |
| ▸ | USP2 | O75604 | 1/20 | 0.49 |
| ▸ | SMN1; SMN2 | Q16637 | 4/20 | 0.48 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
| ▸ | ALOX5AP | P20292 | 2/20 | 0.47 |
| ▸ | FEN1 | P39748 | 2/20 | 0.47 |
| ▸ | HPGD | P15428 | 3/20 | 0.47 |
| ▸ | CCNE2 | O96020 | 1/20 | 0.47 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.47 |
| ▸ | CDK2 | P24941 | 1/20 | 0.47 |
| ▸ | GSK3B | P49841 | 1/20 | 0.47 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
| ▸ | AXL | P30530 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL2558872 | 0.79 | DHFR (0.60) | CDK2 | |
| SCHEMBL6985080 | 0.78 | KMT2A (0.60) | POLBKMT2AGAAMEN1JAK2 | |
| SCHEMBL28267331 | 0.77 | KMT2A (0.52) | POLBKMT2AGAAMEN1JAK2 | |
| SCHEMBL264111 | 0.74 | HRH3 (0.56) | JAK2 | |
| SCHEMBL12793245 | 0.74 | POLB (0.88) | POLBKMT2AGAAMEN1ALDH1A1 | |
| SCHEMBL264497 | 0.73 | NPSR1 (0.51) | KMT2AGAAMEN1ALDH1A1KDM4E | |
| SCHEMBL78621 | 0.73 | POLB (0.73) | POLBKMT2AGAAMEN1ALDH1A1 | |
| SCHEMBL19951018 | 0.73 | ALDH1A1 (0.67) | POLBKMT2AGAAMEN1ALDH1A1 | |
| SCHEMBL13968125 | 0.72 | KCNH2 (0.59) | POLBKMT2AGAAMEN1JAK2 | |
| SCHEMBL2933507 | 0.72 | CCNE2 (0.56) | POLBKMT2AGAAMEN1JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2009017838-A2 | COMBINATIONS OF JAK-2 INHIBITORS AND OTHER AGENTS | EXELIXIS, INC. (US) | 2009-02-05 | — | — | WO | claimed |