Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ROCK2 | O75116 | 5/20 | 0.64 |
| ▸ | AKT2 | P31751 | 1/20 | 0.46 |
| ▸ | JAK1 | P23458 | 6/20 | 0.44 |
| ▸ | TYK2 | P29597 | 4/20 | 0.44 |
| ▸ | JAK3 | P52333 | 4/20 | 0.44 |
| ▸ | ROCK1 | Q13464 | 2/20 | 0.42 |
| ▸ | TNIK | Q9UKE5 | 2/20 | 0.42 |
| ▸ | BRD4 | O60885 | 1/20 | 0.41 |
| ▸ | JAK2 | O60674 | 5/20 | 0.41 |
| ▸ | CIT | O14578 | 1/20 | 0.39 |
| ▸ | TTBK1 | Q5TCY1 | 1/20 | 0.39 |
| ▸ | TTBK2 | Q6IQ55 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL28266115 | 0.86 | ROCK2 (0.61) | ROCK2JAK1TYK2JAK3ROCK1 | |
| SCHEMBL20985823 | 0.83 | ROCK2 (0.63) | ROCK2AKT2JAK1TYK2JAK3 | |
| SCHEMBL17912972 | 0.78 | ROCK2 (0.66) | ROCK2AKT2JAK1TYK2JAK3 | |
| SCHEMBL19643936 | 0.78 | ROCK2 (1.00) | ROCK2AKT2ROCK1TNIK | |
| SCHEMBL19643883 | 0.76 | ROCK2 (0.61) | ROCK2ROCK1TNIK | |
| SCHEMBL19643172 | 0.76 | ROCK2 (1.00) | ROCK2ROCK1TNIK | |
| SCHEMBL20985756 | 0.76 | ROCK2 (0.57) | ROCK2ROCK1 | |
| SCHEMBL13362788 | 0.74 | ROCK2 (0.67) | ROCK2AKT2ROCK1TNIK | |
| SCHEMBL30989471 | 0.71 | ROCK2 (0.53) | ROCK2AKT2JAK1TYK2JAK3 | |
| SCHEMBL3128936 | 0.70 | ROCK2 (0.62) | ROCK2JAK1TYK2JAK3JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| CN-109153663-A | Triazolones and Tetrazolones as ROCK Inhibitors | 百时美施贵宝公司 | 2019-01-04 | — | — | CN | disclosed |