Predicted protein targets (top 9)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 18/20 | 0.59 |
| ▸ | PDE4A | P27815 | 17/20 | 0.59 |
| ▸ | PDE4C | Q08493 | 17/20 | 0.59 |
| ▸ | PDE4D | Q08499 | 17/20 | 0.59 |
| ▸ | MEN1 | O00255 | 1/20 | 0.57 |
| ▸ | NPC1 | O15118 | 1/20 | 0.57 |
| ▸ | RAB9A | P51151 | 1/20 | 0.57 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.57 |
| ▸ | LMNA | P02545 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL558312 | 0.97 | MEN1 (0.61) | PDE4BPDE4APDE4CPDE4DMEN1 | |
| SCHEMBL558606 | 0.95 | MEN1 (0.60) | PDE4BPDE4APDE4CPDE4DMEN1 | |
| SCHEMBL77276 | 0.93 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4DMEN1 | |
| SCHEMBL25382702 | 0.87 | PDE4B (0.48) | PDE4BPDE4APDE4CPDE4DMEN1 | |
| SCHEMBL29858617 | 0.86 | PDE4A (0.49) | PDE4BPDE4APDE4CPDE4DMEN1 | |
| SCHEMBL23325964 | 0.86 | PDE4B (0.53) | PDE4BPDE4APDE4CPDE4DMEN1 | |
| SCHEMBL7381516 | 0.84 | PDE4B (0.75) | PDE4BPDE4APDE4CPDE4DMEN1 | |
| SCHEMBL7762881 | 0.84 | PDE4B (0.60) | PDE4BPDE4APDE4CPDE4DMEN1 | |
| SCHEMBL21820761 | 0.84 | KMT2A (0.52) | PDE4BPDE4APDE4CPDE4DMEN1 | |
| SCHEMBL29858876 | 0.83 | PDE4B (0.47) | PDE4BPDE4APDE4CPDE4DMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2162438-A2 | PROCESS FOR THE PREPARATION OF IVABRADINE HYDROCHLORIDE AND POLYMORPH THEREOF | Ind-Swift Laboratories Limited (IN) | 2010-03-17 | — | — | EP | disclosed |
| WO-2008146308-A9 | PROCESS FOR THE PREPARATION OF IVABRADINE HYDROCHLORIDE AND POLYMORPH THEREOF | IND SWIFT LAB LTD (IN) | 2009-01-15 | — | — | WO | disclosed |
| WO-2008146308-A2 | PROCESS FOR THE PREPARATION OF IVABRADINE HYDROCHLORIDE AND POLYMORPH THEREOF | IND-SWIFT LABORATORIES LIMITED (IN) | 2008-12-04 | — | — | WO | disclosed |
| US-5405866-A | Administering with cytostatic drugs to treat drug resistant tumors | HOFFMANN-LA ROCHE INC. (US) | 1995-04-11 | — | — | US | disclosed |
| US-5302727-A | For use with antitumor agents | HOFFMANN-LA ROCHE INC. (US) | 1994-04-12 | — | — | US | disclosed |
| US-5296482-A | (Benzocycloalkyl) alkylamines | ADIR ET COMPAGNIE (FR) | 1994-03-22 | — | — | US | disclosed |
| EP-0523493-A1 | Dithianes | F. HOFFMANN-LA ROCHE AG (CH) | 1993-01-20 | — | — | EP | disclosed |
| EP-0166937-A2 | Adrenergic compounds | ABBOTT LABORATORIES (US) | 1986-01-08 | — | — | EP | disclosed |