Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 19/20 | 0.53 |
| ▸ | PDE4A | P27815 | 18/20 | 0.53 |
| ▸ | PDE4C | Q08493 | 18/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 18/20 | 0.53 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | NPC1 | O15118 | 1/20 | 0.48 |
| ▸ | RAB9A | P51151 | 1/20 | 0.48 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL77276 | 0.89 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4DMEN1 | |
| SCHEMBL13761090 | 0.87 | OPRM1 (0.47) | PDE4BPDE4APDE4CPDE4DMEN1 | |
| SCHEMBL13761156 | 0.87 | PDE4B (0.44) | PDE4BPDE4APDE4CPDE4DMEN1 | |
| SCHEMBL13526162 | 0.86 | PDE4B (0.73) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL2827366 | 0.86 | PDE4B (0.59) | PDE4BPDE4APDE4CPDE4DMEN1 | |
| SCHEMBL558312 | 0.86 | MEN1 (0.61) | PDE4BPDE4APDE4CPDE4DMEN1 | |
| Hydrochloric Acid SCHEMBL3181049 | 0.85 | PDE4B (0.72) | PDE4BPDE4APDE4CPDE4D | |
| SCHEMBL558606 | 0.84 | MEN1 (0.60) | PDE4BPDE4APDE4CPDE4DMEN1 | |
| SCHEMBL14544227 | 0.84 | PDE4B (0.42) | PDE4BPDE4APDE4CPDE4DMEN1 | |
| SCHEMBL7381516 | 0.81 | PDE4B (0.75) | PDE4BPDE4APDE4CPDE4DMEN1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2021083328-A1 | POLYSUBSTITUTED ISOINDOLINE COMPOUNDS, PREPARATION METHOD THEREFOR, PHARMACEUTICAL COMPOSITION THEREOF AND USE THEREOF | 中国科学院上海药物研究所 | 2021-05-06 | — | — | WO | disclosed |